Research advances of nanoparticles for CAR-T therapy in solid tumors

B Chen, L Gong, J Feng, M Jin, L Chen, Z Gao… - Chinese Chemical …, 2023 - Elsevier
As one of the most promising adoptive T-cell therapies, chimeric antigen receptor T-cell
(CAR-T) therapy has acquired Food and Drug Administration (FDA) approval for a variety of …

[HTML][HTML] In vitro and in vivo evaluation of clinically-approved ionizable cationic lipids shows divergent results between mRNA transfection and vaccine efficacy

O Escalona-Rayo, Y Zeng, RA Knol, TJF Kock… - Biomedicine & …, 2023 - Elsevier
Ionizable cationic lipids (ICLs) play an essential role in the effectiveness of lipid
nanoparticles (LNPs) for delivery of mRNA therapeutics and vaccines; therefore, critical …

[HTML][HTML] Genetically engineered CD80–pMHC-harboring extracellular vesicles for antigen-specific CD4+ T-cell engagement

IA Ishina, IN Kurbatskaia, AE Mamedov… - … in Bioengineering and …, 2024 - frontiersin.org
The identification of low-frequency antigen-specific CD4+ T cells is crucial for effective
immunomonitoring across various diseases. However, this task still encounters experimental …

Immunotherapy Study on Non-small-Cell Lung Cancer (NSCLC) Combined with Cytotoxic T Cells and miRNA34a

R Pandey, CC Chiu, LF Wang - Molecular Pharmaceutics, 2024 - ACS Publications
Immunotherapy has emerged as a promising approach for cancer treatment, and the use of
microRNAs (miRNAs) as therapeutic agents has gained significant attention. In this study …

[HTML][HTML] Biomaterials-mediated ligation of immune cell surface receptors for immunoengineering

H Cui, L Zhang, Y Shi - Immuno-Oncology and Technology, 2024 - Elsevier
Highlights•Cell surface receptors play a vital role in regulating immune responses.•Ligation
of cell surface receptors initiates downstream signaling.•Biomaterials interact with immune …

Nucleation‐Inhibited Emulsion Interfacial Assembled Polydopamine Microvesicles as Artificial Antigen‐Presenting Cells

L Dong, M Liu, M Fang, Q Lu, X Li, Y Ma, T Zhao - Small, 2024 - Wiley Online Library
Albeit microemulsion systems have emerged as efficient platforms for fabricating tunable
nano/microstructures, lack of understanding on the emulsion‐interfacial assembly hindered …

Th1-LIKE HBV-SPECIFIC CD4+ T CELLS ARE ABLE TO REVERT THE CD8+ T CELL DYSFUNCTION INDUCED BY HEPATOCELLULAR PRIMING

V Venzin - 2023 - iris.unisr.it
About 260 million people are chronically infected with hepatitis B virus (HBV), resulting in>
700,000 deaths per year from cirrhosis and hepatocellular carcinoma. Despite the …