The epithelial architecture of the thymus fosters growth, differentiation, and T cell receptor
repertoire selection of large numbers of immature T cells that continuously feed the mature …

In vertebrates, the thymus is the main site of T cell development. The thymus reaches its
maximum output during adolescence, after which it shrinks and generates fewer and fewer T …

The thymus is responsible for generating a diverse yet self-tolerant pool of T cells. Although
the thymic medulla consists mostly of developing and mature AIRE+ epithelial cells, recent …

Mimetic cells are medullary thymic epithelial cells (mTECs) that mimic extra-thymic cell types
to tolerize T cells to self-antigens. Here, we dissected the biology of entero-hepato mTECs …

Patients with loss of function in the gene encoding the master regulator of central tolerance
AIRE suffer from a devastating disorder called autoimmune polyendocrine syndrome type 1 …

Thymic T cell lineage commitment is dependent on Notch1 (N1) receptor–mediated
signaling. Although the physiological ligands that interact with N1 expressed on thymic …

Neuromyelitis optica is a paradigmatic autoimmune disease of the central nervous system,
in which the water-channel protein AQP4 is the target antigen. The immunopathology in …

Fibroblasts are one of the most common but also neglected types of stromal cells, the
heterogeneity of which underlies the specific function of tissue microenvironments in …

Osteoprotegerin (OPG) is a circulating decoy receptor for RANKL, a multifunctional cytokine
essential for the differentiation of tissue-specific cells in bone and immune systems such as …

Thymic involution is central to the decline in immune system function that occurs with age.
By regenerating the thymus, it may therefore be possible to improve the ability of the aged …