As a potentially life threatening side effect, pharmaceutical compounds may trigger cardiac
arrhythmias by impeding the heart's electrical and mechanical function. For this reason, any …

The heart is a hierarchical dynamic system consisting of molecules, cells, and tissues, and
acts as a pump for blood circulation. The pumping function depends critically on the …

Mixed-mode oscillations (MMOs) and canards play important role in the dynamics of many
mathematical models in the life sciences. In particular, pathological early …

Early afterdepolarizations (EADs) are pathological voltage oscillations during the
repolarization phase of cardiac action potentials. They are considered as potential …

We analyze the dynamical mechanisms underlying the formation of arrhythmogenic early
afterdepolarizations (EADs) in two mathematical models of cardiac cellular …

The stochastic Hindmarsh–Rose model is studied in the parameter region where two
bursting limit cycles of different types coexist. We show that under the influence of noise …

Abstract The Hindmarsh–Rose is one of the best-known models of computational
neuroscience. Despite its popularity as a neuron model, we demonstrate that it is also a …

Mitochondria serve multiple key cellular functions, including energy generation, redox
balance, and regulation of apoptotic cell death, thus making a major impact on healthy and …

We study the influence of noise on a mathematical model of the cardiac action potential
described by a three-dimensional system of ordinary differential equations. The original …

Sudden cardiac arrest is a malfunction of the heart's electrical system, typically caused by
ventricular arrhythmias, that can lead to sudden cardiac death (SCD) within minutes …