Molecular damage in aging
Cellular metabolism and environmental interactions generate molecular damage affecting
all levels of biological organization. Accumulation of this damage over time is thought to …
all levels of biological organization. Accumulation of this damage over time is thought to …
[HTML][HTML] Engineering cytosolic acetyl-coenzyme A supply in Saccharomyces cerevisiae: pathway stoichiometry, free-energy conservation and redox-cofactor balancing
HM Van Rossum, BU Kozak, JT Pronk… - Metabolic …, 2016 - Elsevier
Saccharomyces cerevisiae is an important industrial cell factory and an attractive
experimental model for evaluating novel metabolic engineering strategies. Many current and …
experimental model for evaluating novel metabolic engineering strategies. Many current and …
Light-driven fine chemical production in yeast biohybrids
Inorganic-biological hybrid systems have potential to be sustainable, efficient, and versatile
chemical synthesis platforms by integrating the light-harvesting properties of semiconductors …
chemical synthesis platforms by integrating the light-harvesting properties of semiconductors …
Rewiring carbon metabolism in yeast for high level production of aromatic chemicals
The production of bioactive plant compounds using microbial hosts is considered a safe,
cost-competitive and scalable approach to their production. However, microbial production …
cost-competitive and scalable approach to their production. However, microbial production …
The Plasma NAD+ Metabolome Is Dysregulated in “Normal” Aging
Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that serves as
an electron carrier in cellular metabolism and plays a crucial role in the maintenance of …
an electron carrier in cellular metabolism and plays a crucial role in the maintenance of …
Semisynthetic biosensors for mapping cellular concentrations of nicotinamide adenine dinucleotides
We introduce a new class of semisynthetic fluorescent biosensors for the quantification of
free nicotinamide adenine dinucleotide (NAD+) and ratios of reduced to oxidized …
free nicotinamide adenine dinucleotide (NAD+) and ratios of reduced to oxidized …
Whole-cell biocatalysis using cytochrome P450 monooxygenases for biotransformation of sustainable bioresources (fatty acids, fatty alkanes, and aromatic amino …
HA Park, G Park, W Jeon, JO Ahn, YH Yang… - Biotechnology …, 2020 - Elsevier
Cytochrome P450s (CYPs) are heme-thiolated enzymes that catalyze the oxidation of C
single bond H bonds in a regio and stereoselective manner. Activation of the non-activated …
single bond H bonds in a regio and stereoselective manner. Activation of the non-activated …
[HTML][HTML] A comparative analysis of NADPH supply strategies in Saccharomyces cerevisiae: Production of d-xylitol from d-xylose as a case study
Enhancing the supply of the redox cofactor NADPH in metabolically engineered cells is a
critical target for optimizing the synthesis of many product classes, such as fatty acids or …
critical target for optimizing the synthesis of many product classes, such as fatty acids or …
Xylose and shikimate transporters facilitates microbial consortium as a chassis for benzylisoquinoline alkaloid production
Plant-sourced aromatic amino acid (AAA) derivatives are a vast group of compounds with
broad applications. Here, we present the development of a yeast consortium for efficient …
broad applications. Here, we present the development of a yeast consortium for efficient …
Simple phenylpropanoids: recent advances in biological activities, biosynthetic pathways, and microbial production
Z Zhu, R Chen, L Zhang - Natural Product Reports, 2024 - pubs.rsc.org
Covering: 2000 to 2023 Simple phenylpropanoids are a large group of natural products with
primary C6–C3 skeletons. They are not only important biomolecules for plant growth but …
primary C6–C3 skeletons. They are not only important biomolecules for plant growth but …