Simple Summary Wild mice live in territories inhabited by one adult male, several females,
and their offspring. This cannot be replicated in the laboratory, so male mice are usually …

Serotonin [5-hydroxytryptamine (5-HT)] is a multifunctional neurotransmitter innervating
cortical and limbic areas involved in cognition and emotional regulation. Dysregulation of …

The glymphatic system is a network of perivascular spaces that promotes movement of
cerebrospinal fluid (CSF) into the brain and clearance of metabolic waste. This fluid …

Handling is a well-known source of stress to laboratory animals and can affect variability of
results and even compromise animal welfare. The conventional tail handling in mice has …

ABSTRACT A wide range of genetic mouse models is available to help researchers dissect
human disease mechanisms. Each type of model has its own distinctive characteristics …

Animal models of epilepsy and seizures, mostly involving mice and rats, are used to
understand the pathophysiology of the different forms of epilepsy and their comorbidities, to …

Background Traditionally, in biomedical animal research, laboratory rodents are individually
examined in test apparatuses outside of their home cages at selected time points. However …

Nonalcoholic steatohepatitis (NASH), especially as part of the metabolic syndrome (MS), is
an increasing burden in Western countries. Statins are already used in MS and seem to be …

There are no approved treatments for liver fibrosis. To aid development of antifibrotic
therapies, noninvasive biomarkers that can identify patients with progressive fibrosis and …

Supplementation with NAD precursors such as nicotinamide riboside (NR) has been shown
to enhance mitochondrial function in the liver and to prevent hepatic lipid accumulation in …