Resveratrol cocrystals with enhanced solubility and tabletability

Z Zhou, W Li, WJ Sun, T Lu, HHY Tong, CC Sun… - International journal of …, 2016 - Elsevier
Two new 1: 1 cocrystals of resveratrol (RES) with 4-aminobenzamide (RES-4ABZ) and
isoniazid (RES-ISN) were synthesized by liquid assisted grinding (LAG) and rapid solvent …

Identification of new cocrystal systems with stoichiometric diversity of salicylic acid using thermal methods

Z Zhou, HM Chan, HHY Sung, HHY Tong… - Pharmaceutical …, 2016 - Springer
Purpose The purpose of this work was to develop thermal methods to identify cocrystal
systems with stoichiometric diversity. Methods Differential scanning calorimetry (DSC) and …

The enhanced pH-dependent solubility behavior of three novel lamotrigine-acid salts

J Li, Y Zhu, C Zhang, D Yang, Y Lu, Z Zhou - Journal of Molecular Liquids, 2023 - Elsevier
Abstract Lamotrigine (LAM), a Biopharmaceutics Classification System (BCS) class II drug, is
widely used to treat epilepsy, bipolar disorder and neuropathic pain. However, its low …

Enhanced antioxidant activity of ursolic acid by complexation with copper (II): Experimental and theoretical study

M Samsonowicz, M Kalinowska, K Gryko - Materials, 2021 - mdpi.com
The copper (II) complex of ursolic acid (Cu (II) UA) was synthesized and discussed in terms
of its infrared, UV–visible spectra, quantum-chemical calculations at B3LYP/6-31G (d) level …

Two Polymorphic Cocrystals of Theophylline with Ferulic Acid

H Liu, HCS Chan, X Yu, J Li, J Li… - Crystal Growth & Design, 2023 - ACS Publications
In this study, the crystal structures of 1: 1 theophylline–ferulic acid cocrystal polymorphs are
reported for the first time. Interestingly, both forms crystallize in the same space group but …

Therapeutically relevant natural products as AMPK activators in the treatment of diabetes

JM Germán-Acacio, DE Meza-Sánchez… - Studies in natural …, 2020 - Elsevier
Type 2 diabetes mellitus (T2DM) is a chronic condition that requires the administration of
pharmacological and non-pharmacological agents for its treatment. Most pharmaceutical …

PVP solid dispersions containing Poloxamer 407 or TPGS for the improvement of ursolic acid release

AM Pironi, JO Eloy, CF Rodero, SG Antonio… - Brazilian Journal of …, 2023 - SciELO Brasil
Solid dispersions (SDs) of ursolic acid (UA) were developed using polyvinylpyrrolidone K30
(PVP K30) in combination with non-ionic surfactants, such as D-α-tocopherol polyethylene …

Cucumis metuliferus L. Fruits Extract with Antioxidant, Anti-Inflammatory, and Antidiabetic Properties as Source of Ursolic Acid

AC Busuioc, GV Costea, AVD Botezatu, B Furdui… - Separations, 2023 - mdpi.com
To identify healthy, nutritious, and sustainable plant-based products rich in biologically
active compounds, this present study was conducted, and the phytochemical composition …

Colloidal and Biological Characterization of Dual Drug-Loaded Smart Micellar Systems

H Herman, DM Rata, AN Cadinoiu, LI Atanase… - Polymers, 2024 - mdpi.com
Smart polymeric micelles (PMs) are of great interest in drug delivery owing to their low
critical micellar concentration and sizes. In the present study, two different pH-sensitive poly …

Comprehensive exploration of riboflavin solid forms and preparation mechanism of stable forms

Y Shao, W Kuang, X Wan, D Han, S Du… - … Engineering Research and …, 2024 - Elsevier
Riboflavin is a water-soluble vitamin regarded as an essential nutrient participating in
biological oxidation in vivo. The strong hygroscopicity and crystalline phase impurity of …