Resveratrol cocrystals with enhanced solubility and tabletability
Two new 1: 1 cocrystals of resveratrol (RES) with 4-aminobenzamide (RES-4ABZ) and
isoniazid (RES-ISN) were synthesized by liquid assisted grinding (LAG) and rapid solvent …
isoniazid (RES-ISN) were synthesized by liquid assisted grinding (LAG) and rapid solvent …
Identification of new cocrystal systems with stoichiometric diversity of salicylic acid using thermal methods
Purpose The purpose of this work was to develop thermal methods to identify cocrystal
systems with stoichiometric diversity. Methods Differential scanning calorimetry (DSC) and …
systems with stoichiometric diversity. Methods Differential scanning calorimetry (DSC) and …
The enhanced pH-dependent solubility behavior of three novel lamotrigine-acid salts
J Li, Y Zhu, C Zhang, D Yang, Y Lu, Z Zhou - Journal of Molecular Liquids, 2023 - Elsevier
Abstract Lamotrigine (LAM), a Biopharmaceutics Classification System (BCS) class II drug, is
widely used to treat epilepsy, bipolar disorder and neuropathic pain. However, its low …
widely used to treat epilepsy, bipolar disorder and neuropathic pain. However, its low …
Enhanced antioxidant activity of ursolic acid by complexation with copper (II): Experimental and theoretical study
The copper (II) complex of ursolic acid (Cu (II) UA) was synthesized and discussed in terms
of its infrared, UV–visible spectra, quantum-chemical calculations at B3LYP/6-31G (d) level …
of its infrared, UV–visible spectra, quantum-chemical calculations at B3LYP/6-31G (d) level …
Two Polymorphic Cocrystals of Theophylline with Ferulic Acid
H Liu, HCS Chan, X Yu, J Li, J Li… - Crystal Growth & Design, 2023 - ACS Publications
In this study, the crystal structures of 1: 1 theophylline–ferulic acid cocrystal polymorphs are
reported for the first time. Interestingly, both forms crystallize in the same space group but …
reported for the first time. Interestingly, both forms crystallize in the same space group but …
Therapeutically relevant natural products as AMPK activators in the treatment of diabetes
JM Germán-Acacio, DE Meza-Sánchez… - Studies in natural …, 2020 - Elsevier
Type 2 diabetes mellitus (T2DM) is a chronic condition that requires the administration of
pharmacological and non-pharmacological agents for its treatment. Most pharmaceutical …
pharmacological and non-pharmacological agents for its treatment. Most pharmaceutical …
PVP solid dispersions containing Poloxamer 407 or TPGS for the improvement of ursolic acid release
Solid dispersions (SDs) of ursolic acid (UA) were developed using polyvinylpyrrolidone K30
(PVP K30) in combination with non-ionic surfactants, such as D-α-tocopherol polyethylene …
(PVP K30) in combination with non-ionic surfactants, such as D-α-tocopherol polyethylene …
Cucumis metuliferus L. Fruits Extract with Antioxidant, Anti-Inflammatory, and Antidiabetic Properties as Source of Ursolic Acid
To identify healthy, nutritious, and sustainable plant-based products rich in biologically
active compounds, this present study was conducted, and the phytochemical composition …
active compounds, this present study was conducted, and the phytochemical composition …
Colloidal and Biological Characterization of Dual Drug-Loaded Smart Micellar Systems
H Herman, DM Rata, AN Cadinoiu, LI Atanase… - Polymers, 2024 - mdpi.com
Smart polymeric micelles (PMs) are of great interest in drug delivery owing to their low
critical micellar concentration and sizes. In the present study, two different pH-sensitive poly …
critical micellar concentration and sizes. In the present study, two different pH-sensitive poly …
Comprehensive exploration of riboflavin solid forms and preparation mechanism of stable forms
Y Shao, W Kuang, X Wan, D Han, S Du… - … Engineering Research and …, 2024 - Elsevier
Riboflavin is a water-soluble vitamin regarded as an essential nutrient participating in
biological oxidation in vivo. The strong hygroscopicity and crystalline phase impurity of …
biological oxidation in vivo. The strong hygroscopicity and crystalline phase impurity of …