Unbalanced Th1/Th2 T‐cell responses in the liver are a characteristic of hepatic
inflammation and subsequent liver fibrosis. The recently discovered Th17 cells, a subtype of …

Chemokines are a class of small cytokines or signaling proteins that are secreted by cells.
Owing to their ability to induce directional chemotaxis of nearby responding cells, they are …

Tumors evade immune destruction by actively inducing immune tolerance through the
recruitment of CD4+ CD25+ Foxp3+ regulatory T cells (Treg). We have previously described …

CXC chemokine receptor 3 (CXCR3) is the receptor for the IFN-γ–inducible CXC
chemokines MIG/CXCL9, IP-10/CXCL10, and I-TAC/CXCL11. CXCR3 is expressed on …

In papillary thyroid carcinomas (PTCs), rearrangements of the RET receptor (RET/PTC) and
activating mutations in the BRAF or RAS oncogenes are mutually exclusive. Here we show …

Chemokines and their receptors have principal roles in leukocyte trafficking under normal
physiological and pathological conditions. The differential expression of the chemokine …

CXC chemokines are involved in chemotaxis, regulation of cell growth, induction of
apoptosis and modulation of angiostatic effects. CXCL9, CXCL10, CXCL11, CXCL4 and its …

Rheumatoid arthritis (RA) is a chronic inflammatory disease leading to joint destruction (1).
In RA, migration of leukocytes into the synovial tissue (ST) occurs. These leukocytes and …

Regulatory T cells (Tregs) play a crucial physiological role in the regulation of immune
homeostasis, although recent data suggest Tregs can contribute to primary tumor growth by …

Chemokines are a family of soluble cytokines that act as chemoattractants to guide the
migration of cells, in particular of immune cells. However, chemokines are also involved in …