Mitochondrial proteins: from biogenesis to functional networks
N Pfanner, B Warscheid, N Wiedemann - Nature reviews Molecular cell …, 2019 - nature.com
Mitochondria are essential for the viability of eukaryotic cells as they perform crucial
functions in bioenergetics, metabolism and signalling and have been associated with …
functions in bioenergetics, metabolism and signalling and have been associated with …
Mass-spectrometric exploration of proteome structure and function
R Aebersold, M Mann - Nature, 2016 - nature.com
Numerous biological processes are concurrently and coordinately active in every living cell.
Each of them encompasses synthetic, catalytic and regulatory functions that are, almost …
Each of them encompasses synthetic, catalytic and regulatory functions that are, almost …
Ultra-fast label-free quantification and comprehensive proteome coverage with narrow-window data-independent acquisition
Mass spectrometry (MS)-based proteomics aims to characterize comprehensive proteomes
in a fast and reproducible manner. Here we present the narrow-window data-independent …
in a fast and reproducible manner. Here we present the narrow-window data-independent …
On the dependency of cellular protein levels on mRNA abundance
The question of how genomic information is expressed to determine phenotypes is of central
importance for basic and translational life science research and has been studied by …
importance for basic and translational life science research and has been studied by …
SCoPE-MS: mass spectrometry of single mammalian cells quantifies proteome heterogeneity during cell differentiation
Some exciting biological questions require quantifying thousands of proteins in single cells.
To achieve this goal, we develop Single Cell ProtEomics by Mass Spectrometry (SCoPE …
To achieve this goal, we develop Single Cell ProtEomics by Mass Spectrometry (SCoPE …
The Perseus computational platform for comprehensive analysis of (prote) omics data
A main bottleneck in proteomics is the downstream biological analysis of highly multivariate
quantitative protein abundance data generated using mass-spectrometry-based analysis …
quantitative protein abundance data generated using mass-spectrometry-based analysis …
Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed MaxLFQ
Protein quantification without isotopic labels has been a long-standing interest in the
proteomics field. However, accurate and robust proteome-wide quantification with label-free …
proteomics field. However, accurate and robust proteome-wide quantification with label-free …
Relationship between differentially expressed mRNA and mRNA-protein correlations in a xenograft model system
Differential mRNA expression studies implicitly assume that changes in mRNA expression
have biological meaning, most likely mediated by corresponding changes in protein levels …
have biological meaning, most likely mediated by corresponding changes in protein levels …
Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells
Mass spectrometry (MS)-based proteomics typically employs multistep sample-preparation
workflows that are subject to sample contamination and loss. We report an in-StageTip …
workflows that are subject to sample contamination and loss. We report an in-StageTip …
Six alternative proteases for mass spectrometry–based proteomics beyond trypsin
Protein digestion using a dedicated protease represents a key element in a typical mass
spectrometry (MS)-based shotgun proteomics experiment. Up to now, digestion has been …
spectrometry (MS)-based shotgun proteomics experiment. Up to now, digestion has been …