Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by a failure of
spontaneous resolution of inflammation. Although the pro-inflammatory cytokines and …

Individuals at high risk of developing seropositive rheumatoid arthritis (RA) can be identified
for translational research and disease prevention studies through the presence of highly …

Numerous rheumatologic autoimmune diseases, among which rheumatoid arthritis, are
chronic inflammatory diseases capable of inducing multiple cumulative articular and extra …

Objective Anticitrullinated protein antibodies (ACPA) are a major risk factor for bone loss in
rheumatoid arthritis (RA). We have recently shown that ACPA directly induce bone loss by …

Objectives The relationship of immune dysregulation and autoantibody production that may
contribute to systemic lupus erythematosus (SLE) pathogenesis is unknown. This study …

Successful therapeutic stratification will depend upon an increasingly sophisticated
appreciation of how dominant players amongst cytokine networks vary across time and …

Rheumatoid arthritis (RA) is an autoimmune disease characterized in seropositive
individuals by the presence of anti-cyclic citrullinated protein (CCP) antibodies. RA is linked …

Introduction Discrimination of rheumatoid arthritis (RA) patients from patients with other
inflammatory or degenerative joint diseases or healthy individuals purely on the basis of …

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a poorly
understood preclinical stage of immune dysregulation and symptom accrual. Accumulation …

Investigations are needed to determine when and where RA begins, including
comprehensive prospective studies of individuals in the preclinical period of RA that can …