ATG8 family proteins are evolutionary conserved ubiquitin-like modifiers, which become
attached to the headgroup of the membrane lipid phosphatidylethanolamine in a process …

Autophagy is a well-known cell-survival strategy orchestrated by a conserved set of proteins.
It equips the cells with mechanisms to attain homeostasis during unfavorable conditions …

PINK1-Parkin mediated mitophagy, a selective form of autophagy, represents one of the
most important mechanisms in mitochondrial quality control (MQC) via the clearance of …

The biogenesis of mammalian autophagosomes remains to be fully defined. Here, we used
cellular and in vitro membrane fusion analyses to show that autophagosomes are formed …

We report that lysosomal damage is a hitherto unknown inducer of stress granule (SG)
formation and that the process termed membrane atg8ylation coordinates SG formation with …

Autophagy and endocytosis are membrane-vesicle-based cellular pathways for degradation
and recycling of intracellular and extracellular components, respectively. These pathways …

Autophagy is a homeostatic process with multiple functions in mammalian cells. Here, we
show that mammalian Atg8 proteins (mAtg8s) and the autophagy regulator IRGM control …

Intracellular membrane protein trafficking is crucial for both normal cellular physiology and
cell-cell communication. The conventional secretory route follows transport from the …

Autophagosome–lysosome fusion mediated by SNARE complexes is an essential step in
autophagy. Two SNAP29-containing SNARE complexes have been extensively studied in …

Autophagy and the lysosomal system, together referred to as the autophagolysosomal
system, is a cellular quality control network which maintains cellular health and homeostasis …