Elucidating the biology of yeast in its full complexity has major implications for science,
medicine and industry. One of the most critical processes determining yeast life and …

How do cells age and die? For the past 20 years, the budding yeast, Saccharomyces
cerevisiae, has been used as a model organism to uncover the genes that regulate lifespan …

Though plastic nanoparticles have already raised much concern for their potential impact on
health, our understanding of their biological effects is still utterly limited. Here we …

Lysosomal membrane permeabilization (LMP) is a poorly understood regulator of
programmed cell death that involves leakage of luminal lysosomal or vacuolar hydrolases …

The cell wall is an important cell structure in both fungi and bacteria, and hence becomes a
common antimicrobial target. The cell wall-perturbing agents disrupt synthesis and function …

Unicellular eukaryotes have been suggested to undergo self-inflicted destruction. However,
molecular details are sparse compared with the mechanisms of programmed/regulated cell …

The unfolded protein response (UPR) represents a mechanism to preserve endoplasmic
reticulum (ER) homeostasis that is conserved in eukaryotes. ER stress caused by the …

Programmed cell death (self-induced) is intrinsic to all cellular life forms, including
unicellular organisms. However, cell death research has focused on animal models to …

The study of cell death mechanisms in fungi, particularly yeasts, has gained substantial
interest in recent decades driven by the potential for biotechnological advancements and …

Fungal pathogens pose an increasing threat to public health. Limited clinical drug regimens
and emerging drug-resistant isolates challenge infection control. The global burden of …