The quantum nature of electrons and nuclei is manifested in countless biological events
including the rearrangements of electrons in biochemical reactions, electron and proton …

Highlights•Protein association rate constants are essential for cellular functions.•Half of the
problem of modeling association kinetics has a solution.•Binding of disordered proteins …

The spike (S) glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) is responsible for the binding to the permissive cells. The receptor-binding domain (RBD) …

Genome-scale network reconstruction has enabled predictive modeling of metabolism for
many systems. Traditionally, protein structural information has not been represented in such …

Background The success of genome-scale models (GEMs) can be attributed to the high-
quality, bottom-up reconstructions of metabolic, protein synthesis, and transcriptional …

Genome-Wide Association Studies (GWAS), whole genome sequencing, and high-
throughput omics techniques have generated vast amounts of genotypic and molecular …

The expansion of high-quality, low-cost sequencing has created an enormous opportunity to
understand how genetic variants alter cellular behaviour in disease. The high diversity of …

Structural systems pharmacology offers a novel way of approaching drug discovery by
considering the global physiological environment of protein targets, and the effects derived …

As malignant transformation requires synchronization of growth-driving signaling (S) and
metabolic (M) pathways, defining cancer-specific SM interconnected networks (SMINs) …

A huge amount of genetic information is available thanks to the recent advances in
sequencing technologies and the larger computational capabilities, but the interpretation of …