Azoospermia affects 1% of men, and it can be due to:(i) hypothalamic-pituitary
dysfunction,(ii) primary quantitative spermatogenic disturbances,(iii) urogenital duct …

ABSTRACT BACKGROUND The unbalanced transmission of chromosomes in human
gametes and early preimplantation embryos causes aneuploidy, which is a major cause of …

Brain ischemia elicits microglial activation and microglia survival depend on signaling
through colony-stimulating factor 1 receptor (CSF1R). Although depletion of microglia has …

Meiosis is one of the defining events in gametogenesis. Male and female germ cells both
undergo one round of meiotic cell division during their development in order to reduce the …

BACKGROUND Meiosis is an essential stage in the life cycle of sexually reproducing
species, underlying formation of haploid gametes and serving as the basis of genetic …

Cohesin is an evolutionary conserved multi‐protein complex that plays a pivotal role in
chromosome dynamics. It plays a role both in sister chromatid cohesion and in establishing …

The meiotic chromosome axis plays key roles in meiotic chromosome organization and
recombination, yet the underlying protein components of this structure are highly diverged …

Chromatin architecture mapping in 3D formats has increased our understanding of how
regulatory sequences and gene expression are connected and regulated in a genome. The …

One of the most fascinating aspects of meiosis is the extensive reorganization of the genome
at the prophase of the first meiotic division (prophase I). The first steps of this reorganization …

Idiopathic or “unexplained” infertility represents as many as 30% of infertility cases
worldwide. Conception, implantation, and term delivery of developmentally healthy infants …