Endocytic mechanisms control the lipid and protein composition of the plasma membrane,
thereby regulating how cells interact with their environments. Here, we review what is known …

The cytoskeleton is an interconnected network that provides support and organization to
cells. In eukaryotes, its main components include actin and microtubules, two types of …

Dual colour total internal reflection fluorescence microscopy is a powerful tool for decoding
the molecular dynamics of clathrin-mediated endocytosis (CME). Typically, the recruitment of …

Endocytosis includes a number of processes by which cells internalize segments of their
plasma membrane, enclosing a wide variety of material from outside the cell. Endocytosis …

Cell motility is regulated by multiple processes, including cell protrusion, cell retraction, cell–
matrix adhesion, polarized exocytosis and polarized vesicle trafficking, each of which is …

The endocytic pathway is essential for processes that define how cells interact with their
environment, including receptor signalling, cell adhesion and migration, pathogen entry …

The GTPase dynamin, a key player in endocytic membrane fission, interacts with numerous
proteins that regulate actin dynamics and generate/sense membrane curvature. To …

Genetic studies of hereditary forms of nephrotic syndrome have identified several proteins
that are involved in regulating the permselective properties of the glomerular filtration …

Background Focal segmental glomerulosclerosis is a kidney disease that is manifested as
the nephrotic syndrome. It is often resistant to glucocorticoid therapy and progresses to end …

Phagocytosis requires rapid actin reorganization and spatially controlled force generation to
ingest targets ranging from pathogens to apoptotic cells. How actomyosin activity directs …