[HTML][HTML] The lymphatic vasculature in the 21st century: novel functional roles in homeostasis and disease

G Oliver, J Kipnis, GJ Randolph, NL Harvey - Cell, 2020 - cell.com
Mammals have two specialized vascular circulatory systems: the blood vasculature and the
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …

Advances in lymphedema

SG Rockson - Circulation research, 2021 - Am Heart Assoc
Lymphedema is a common, complex, and inexplicably underappreciated human disease.
Despite a history of relative neglect by health care providers and by governmental health …

[HTML][HTML] Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system

X Li, L Qi, D Yang, SJ Hao, F Zhang, X Zhu, Y Sun… - Nature …, 2022 - nature.com
Recent studies have demonstrated that brain meningeal lymphatic vessels (MLVs) act as a
drainage path directly into the cervical lymph nodes (CLNs) for macromolecules contained …

Regulation of VEGFR signalling in lymphatic vascular development and disease: an update

GA Secker, NL Harvey - International journal of molecular sciences, 2021 - mdpi.com
The importance of lymphatic vessels in a myriad of human diseases is rapidly gaining
recognition; lymphatic vessel dysfunction is a feature of disorders including congenital …

CNS-draining meningeal lymphatic vasculature: roles, conundrums and future challenges

SP das Neves, N Delivanoglou… - Frontiers in …, 2021 - frontiersin.org
A genuine and functional lymphatic vascular system is found in the meninges that sheath the
central nervous system (CNS). This unexpected (re) discovery led to a reevaluation of CNS …

Biomechanical control of lymphatic vessel physiology and functions

V Angeli, HY Lim - Cellular & Molecular Immunology, 2023 - nature.com
The ever-growing research on lymphatic biology has clearly identified lymphatic vessels as
key players that maintain human health through their functional roles in tissue fluid …

[HTML][HTML] Development and aging of the lymphatic vascular system

A González-Loyola, TV Petrova - Advanced Drug Delivery Reviews, 2021 - Elsevier
The lymphatic vasculature has a pivotal role in regulating body fluid homeostasis, immune
surveillance and dietary fat absorption. The increasing number of in vitro and in vivo studies …

Promoting lymphangiogenesis and lymphatic growth and remodeling to treat cardiovascular and metabolic diseases

X Liu, K Cui, H Wu, KS Li, Q Peng, D Wang… - … , and vascular biology, 2023 - Am Heart Assoc
Lymphatic vessels are low-pressure, blind-ended tubular structures that play a crucial role in
the maintenance of tissue fluid homeostasis, immune cell trafficking, and dietary lipid uptake …

Development and physiological functions of the lymphatic system: insights from human genetic studies of primary lymphedema

S Martin-Almedina, PS Mortimer… - Physiological …, 2021 - journals.physiology.org
Primary lymphedema is a long-term (chronic) condition characterized by tissue lymph
retention and swelling that can affect any part of the body, although it usually develops in the …

Angiogenesis—An Emerging Role in Organ Fibrosis

D Wang, Y Zhao, Y Zhou, S Yang, X Xiao… - International Journal of …, 2023 - mdpi.com
In recent years, the study of lymphangiogenesis and fibrotic diseases has made
considerable achievements, and accumulating evidence indicates that lymphangiogenesis …