Pain can become a chronic and deliberating experience with a significant burden. In
preclinical and clinical studies, Saffron (Crocus sativus L.) has shown analgesic activities …

Crocus sativus L.(C. sativus), known as “plant gold”, has numerous functions in traditional
Chinese medicine, including promoting blood circulation, removing blood stasis, cooling …

Many neurons undergo apoptosis after ischemic stroke. In the brain, neurogenesis has the
potential for neuronal replacement and can be activated by external conditions to repair the …

Background Evidence suggests that menopause can be associated with a variety of
negative psychological changes such as depression and anxiety, and improving the mental …

Introduction Several systematic reviews and meta-analyses have been carried out to assess
the impact of synbiotics on lipid profiles and anthropometric parameters. In this regard, an …

Rationale Depression is a serious mood disorder, and crocetin has a variety of
pharmacological activities, including antidepressant effect. The alterations of intestinal flora …

Saffron, indicated as “the red gold,” is an extraordinary spice with a unique aroma and
organoleptic properties that is largely diffused in food preparation as well as a traditional …

Aims Several meta-analyses exist supporting the beneficial effects of curcumin
supplementation on lipid profile parameters; however, some studies' findings are …

Widespread musculoskeletal pain characterizes fibromyalgia (FM), accompanied by sleep,
fatigue, and mood problems. Chronic stress and depression play a crucial role in the …

Background Major depressive disorder affects more than 300 million people worldwide yet
the pathophysiology is not fully understood. This review aimed to investigate the mechanistic …