Although the full aetiology of autism spectrum disorder (ASD) is unknown, familial and twin
studies demonstrate high heritability of 60–90%, indicating a predominant role of genetics in …

Background The non-prescription medication paracetamol (acetaminophen, APAP) is
currently recommended as a safe pain and fever treatment during pregnancy. However …

Abstract Background Autism and Autism Spectrum Disorder (ASD) are complex
neurodevelopmental disorders. Susceptibility is believed to be the interaction of genetic …

The wide range of factors associated with the induction of autism is invariably linked with
either inflammation or oxidative stress, and sometimes both. The use of acetaminophen in …

To achieve sensitive and specific mechanism-based prediction of drug toxicity, the tools of
systems pharmacology will be integrated using structured ontological approaches, analytics …

One of the major organs in the body with multiple functions is the liver. It plays a central role
in the transformation of macronutrients and clearance of chemicals and drugs. The serum …

Abstract In 2019 California's Office of Environmental Health Hazard Assessment (OEHHA)
initiated a review of the carcinogenic hazard potential of acetaminophen. In parallel with this …

Biomarker measurements that reliably correlate with tissue injury and that can be measured
within accessible biofluids offer benefits in terms of cost, time, and convenience when …

Aims Acetaminophen is the medication of choice when treating fever because of its limited
anti-inflammatory effects. However at overdose it can cause mitochondrial dysfunction and …

The human transcriptome is complex, comprising multiple transcript types, mostly in the form
of non‐coding RNA (ncRNA). The majority of ncRNA is of the long form (lncRNA,≥ 200 bp) …