Background Viral-borne diseases are amongst the oldest diseases known to mankind. They
are responsible for some of the most ravaging effects wrought on human health and well …

Herpes simplex virus (HSV), an alphaherpesvirus, is highly prevalent in the human
population and is known to cause oral and genital herpes and various complications …

Intrauterine infections during pregnancy by herpes simplex virus (HSV) can cause significant
neurodevelopmental deficits in the unborn/newborn, but clinical studies of pathogenesis are …

The total synthesis of four novel mono-methoxy and hydroxyl substituted ring-A
dihydronarciclasine derivatives enabled identification of the 7-hydroxyl derivative as a …

Zika virus is a mosquito-borne flavivirus that has emerged recently and affected in many
countries. Since its discovery in Uganda in 1947, two major outbreaks were reported from …

Drug-resistant variants of herpes simplex viruses (HSV) have been reported that are not
effectively treated with first-line antiviral agents. The objective of this study was to evaluate …

The synthesis of a lead anti-viral cyclopropyl carboxy acyl hydrazone 4F17 (5) and three
sequential arrays of structural analogues along with the initial assessment and optimization …

Background Drug repurposing is a cost-effective strategy to identify drugs with novel effects.
We searched for drugs exhibiting inhibitory activity to Herpes Simplex virus 1 (HSV-1). Our …

Zika virus (ZIKV) is a Flavivirus belonging to the Flaviviridae family transmitted by an infected
Aedes aegypti mosquito's bite. Although it is not a highly lethal infection; however, it is …

A synthesis of densely functionalised α-acyloxy enaminals and enaminones via a novel
homogeneous silver (I) catalyzed rearrangement of 1-acyloxy-3-azido ketones is reported …