Aging is the most prominent risk factor for late-onset Alzheimer's disease. Aging associates
with a chronic inflammatory state both in the periphery and in the central nervous system, the …

A major immunopathological feature of Coronavirus disease-2019 (COVID-19) is excessive
inflammation in the form of “cytokine storm”. The storm is characterized by injurious levels of …

Background Neuroinflammation and microglia play critical roles in the development of
depression. Cluster of differentiation 200 (CD200) is an anti-inflammatory glycoprotein that …

Aging attenuates the overall responsiveness of the immune system to eradicate pathogens.
The increased production of pro-inflammatory cytokines by innate immune cells under basal …

Sex differences are present in brain morphology, sex hormones, aging processes and
immune responses. These differences need to be considered for proper modelling of …

Regenerative medicine harnesses the body's innate capacity for self-repair to restore
malfunctioning tissues and organs. Stem cell therapies represent a key regenerative …

The intracellular deposition and intercellular transmission of α-synuclein (α-syn) are shared
pathological characteristics among neurodegenerative disorders collectively known as α …

Cancer and cardiovascular disorders are known as the two main leading causes of mortality
worldwide. Cardiotoxicity is a critical and common adverse effect of cancer-related …

The discovery of the P2X7 receptor (P2X7R, originally named P2Z) in immune cells, its
cloning, and the identification of its role in a multiplicity of immune-mediated diseases raised …

The chemokine fractalkine (FKN, CX3CL1), a member of the CX3C subfamily, contributes to
neuron–glia interaction and the regulation of microglial cell activation. Fractalkine is …