[HTML][HTML] Molecular mechanisms of neuroinflammation in aging and Alzheimer's disease progression
FL Andronie-Cioara, AI Ardelean… - International journal of …, 2023 - mdpi.com
Aging is the most prominent risk factor for late-onset Alzheimer's disease. Aging associates
with a chronic inflammatory state both in the periphery and in the central nervous system, the …
with a chronic inflammatory state both in the periphery and in the central nervous system, the …
[HTML][HTML] Is neuropilin-1 the neuroimmune initiator of multi-system hyperinflammation in COVID-19?
K Saleki, P Alijanizadeh, A Azadmehr - Biomedicine & Pharmacotherapy, 2023 - Elsevier
A major immunopathological feature of Coronavirus disease-2019 (COVID-19) is excessive
inflammation in the form of “cytokine storm”. The storm is characterized by injurious levels of …
inflammation in the form of “cytokine storm”. The storm is characterized by injurious levels of …
[HTML][HTML] CD200 in dentate gyrus improves depressive-like behaviors of mice through enhancing hippocampal neurogenesis via alleviation of microglia hyperactivation
X Chen, QQ Cui, XH Hu, J Ye, ZC Liu, YX Mei… - Journal of …, 2023 - Springer
Background Neuroinflammation and microglia play critical roles in the development of
depression. Cluster of differentiation 200 (CD200) is an anti-inflammatory glycoprotein that …
depression. Cluster of differentiation 200 (CD200) is an anti-inflammatory glycoprotein that …
[HTML][HTML] Counteracting Immunosenescence—Which Therapeutic Strategies Are Promising?
C Hieber, S Grabbe, M Bros - Biomolecules, 2023 - mdpi.com
Aging attenuates the overall responsiveness of the immune system to eradicate pathogens.
The increased production of pro-inflammatory cytokines by innate immune cells under basal …
The increased production of pro-inflammatory cytokines by innate immune cells under basal …
[HTML][HTML] Complexity of sex differences and their impact on Alzheimer's disease
M Kadlecova, K Freude, H Haukedal - Biomedicines, 2023 - mdpi.com
Sex differences are present in brain morphology, sex hormones, aging processes and
immune responses. These differences need to be considered for proper modelling of …
immune responses. These differences need to be considered for proper modelling of …
[HTML][HTML] Harnessing the stem cell niche in regenerative medicine: innovative avenue to combat neurodegenerative diseases
Regenerative medicine harnesses the body's innate capacity for self-repair to restore
malfunctioning tissues and organs. Stem cell therapies represent a key regenerative …
malfunctioning tissues and organs. Stem cell therapies represent a key regenerative …
[HTML][HTML] The involvement of α-synucleinopathy in the disruption of microglial homeostasis contributes to the pathogenesis of Parkinson's disease
Y Miao, H Meng - Cell Communication and Signaling, 2024 - Springer
The intracellular deposition and intercellular transmission of α-synuclein (α-syn) are shared
pathological characteristics among neurodegenerative disorders collectively known as α …
pathological characteristics among neurodegenerative disorders collectively known as α …
[HTML][HTML] Empagliflozin treatment of cardiotoxicity: A comprehensive review of clinical, immunobiological, neuroimmune, and therapeutic implications
Cancer and cardiovascular disorders are known as the two main leading causes of mortality
worldwide. Cardiotoxicity is a critical and common adverse effect of cancer-related …
worldwide. Cardiotoxicity is a critical and common adverse effect of cancer-related …
[HTML][HTML] The coming of age of the P2X7 receptor in diagnostic medicine
F Di Virgilio, V Vultaggio-Poma, S Falzoni… - International Journal of …, 2023 - mdpi.com
The discovery of the P2X7 receptor (P2X7R, originally named P2Z) in immune cells, its
cloning, and the identification of its role in a multiplicity of immune-mediated diseases raised …
cloning, and the identification of its role in a multiplicity of immune-mediated diseases raised …
[HTML][HTML] Age-dependent changes on fractalkine forms and their contribution to neurodegenerative diseases
J Eugenín, L Eugenín-von Bernhardi… - Frontiers in molecular …, 2023 - frontiersin.org
The chemokine fractalkine (FKN, CX3CL1), a member of the CX3C subfamily, contributes to
neuron–glia interaction and the regulation of microglial cell activation. Fractalkine is …
neuron–glia interaction and the regulation of microglial cell activation. Fractalkine is …