During the extended clinically latent period associated with Human Immunodeficiency Virus
(HIV) infection the virus itself is far from latent. This phase of infection generally comes to an …

More than 200 mutations are associated with antiretroviral resistance to drugs belonging to
six licensed antiretroviral classes. More than 50 reverse transcriptase mutations are …

Countries in sub-Saharan Africa were once dismissed by Western experts as being too poor
and chaotic to benefit from the antiretroviral drugs that transformed the AIDS epidemic in the …

The article presents guidelines from the British HIV Association for the treatment of HIV-1-
infected adults using antiretroviral therapy. It presents data from clinical trials on the …

Vaccine candidates for HIV-1 so far have not been able to elicit broadly neutralizing
antibodies (bNAbs) although they express the epitopes recognized by bNAbs to the HIV …

The most common human viruses have different abilities to establish persistent chronic
infection. Virus‐specific T‐cell responses are critical in the control of virus replication and in …

We describe a novel model and algorithm for simultaneously estimating multiple molecular
sequence alignments and the phylogenetic trees that relate the sequences. Unlike current …

Objective: To determine the distribution of HIV-1 subtypes and the prevalence of transmitted
drug resistance-associated mutations (TDRM) among persons newly diagnosed with HIV-1 …

In the mid-1990s, the clinical care of patients with HIV infection changed fundamentally as a
result of the development and introduction of effective antiretroviral therapy (ART). This led …

A key challenge in the quest toward an HIV-1 vaccine is design of immunogens that can
generate a broadly neutralizing antibody (bnAb) response against the enormous sequence …