Cdk5 and aberrant cell cycle activation at the core of neurodegeneration
R Requejo-Aguilar - Neural Regeneration Research, 2023 - journals.lww.com
Neurodegenerative diseases are caused by the progressive loss of specific neurons. The
exact mechanisms of action of these diseases are unknown, and many studies have focused …
exact mechanisms of action of these diseases are unknown, and many studies have focused …
Paeoniflorin is a promising natural monomer for neurodegenerative diseases via modulation of Ca2+ and ROS homeostasis
Neurodegenerative diseases (NDDs) are a range of neurological disorders featured by
neuronal degeneration and apoptosis. Cellular Calcium (Ca 2+) and reactive oxygen …
neuronal degeneration and apoptosis. Cellular Calcium (Ca 2+) and reactive oxygen …
Small molecule '4ab'induced autophagy and endoplasmic reticulum stress-mediated death of aggressive cancer cells grown under adherent and floating conditions
Metastasis is the leading cause of death in cancer patients and a major challenging aspect
of cancer biology. Various adaptive molecular signaling pathways play a crucial role in …
of cancer biology. Various adaptive molecular signaling pathways play a crucial role in …
Key genes and biochemical networks in various brain regions affected in Alzheimer's disease
M Abyadeh, N Tofigh, S Hosseinian, M Hasan… - Cells, 2022 - mdpi.com
Alzheimer's disease (AD) is one of the most complicated progressive neurodegenerative
brain disorders, affecting millions of people around the world. Ageing remains one of the …
brain disorders, affecting millions of people around the world. Ageing remains one of the …
Neuroprotective effects of catechin and quercetin in experimental Parkinsonism through modulation of dopamine metabolism and expression of IL-1β, TNF-α, NF-κB …
The neurobehavioral, brain redox-stabilizing and neurochemical modulatory properties of
catechin and quercetin in rotenone-induced Parkinsonism, and the involvement of NF-κB …
catechin and quercetin in rotenone-induced Parkinsonism, and the involvement of NF-κB …
Bioinformatics and system biology approaches to identify pathophysiological impact of COVID-19 to the progression and severity of neurological diseases
Abstract The Coronavirus Disease 2019 (COVID-19) still tends to propagate and increase
the occurrence of COVID-19 across the globe. The clinical and epidemiological analyses …
the occurrence of COVID-19 across the globe. The clinical and epidemiological analyses …
Triaging between post-translational modification of cell cycle regulators and their therapeutics in neurodegenerative diseases
Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and
Huntington's disease, present challenges in healthcare because of their complicated …
Huntington's disease, present challenges in healthcare because of their complicated …
Tau promotes oxidative stress-associated cycling neurons in S phase as a pro-survival mechanism: Possible implication for Alzheimer's disease
M Denechaud, S Geurs, T Comptdaer, S Bégard… - Progress in …, 2023 - Elsevier
Multiple lines of evidence have linked oxidative stress, tau pathology and neuronal cell cycle
re-activation to Alzheimer's disease (AD). While a prevailing idea is that oxidative stress …
re-activation to Alzheimer's disease (AD). While a prevailing idea is that oxidative stress …
[HTML][HTML] A sporadic Alzheimer's blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies
JM Wasielewska, JCS Chaves, RL Johnston… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: The blood-brain barrier (BBB) is a major impediment to therapeutic intracranial
drug delivery for the treatment of neurodegenerative diseases, including Alzheimer's …
drug delivery for the treatment of neurodegenerative diseases, including Alzheimer's …
Pumpkin extract and fermented whey individually and in combination alleviated AFB1-and OTA-induced alterations on neuronal differentiation in vitro
Food and feed are daily exposed to mycotoxin contamination which effects may be
counteracted by functional compounds like carotenoids and fermented whey. Among …
counteracted by functional compounds like carotenoids and fermented whey. Among …