Abstract Changes to the conformation of coding and non-coding RNAs form the basis of
elements of genetic regulation and provide an important source of complexity, which drives …

RNA dynamics play a fundamental role in many cellular functions. However, there is no
general framework to describe these complex processes, which typically consist of many …

Current approaches used to identify protein-binding small molecules are not suited for
identifying small molecules that can bind emerging RNA drug targets. By docking small …

Riboswitches are gene regulation elements within RNA that recognize specific metabolites.
They predominantly occur in the untranslated leader regions of bacterial messenger RNA …

Riboswitches are gene regulation elements in mRNA that function by specifically
responding to metabolites. Although the metabolite-bound states of riboswitches have …

Vascular endothelial growth factor A (VEGFA) stimulates angiogenesis in human endothelial
cells, and increasing its expression is a potential treatment for heart failure. Here, we report …

Biomolecules form dynamic ensembles of many inter-converting conformations which are
key for understanding how they fold and function. However, determining ensembles is …

The ability to modulate alignment and measure multiple independent sets of NMR residual
dipolar couplings (RDCs) has made it possible to characterize internal motions in proteins at …

We review the role conformational ensembles can play in the analysis of biomolecular
dynamics, molecular recognition, and allostery. We introduce currently available methods for …

RNA is an immensely important target for small molecule therapeutics or chemical probes of
function. However, methods that identify, annotate, and optimize RNA-small molecule …