Background: Emotional disorders are common comorbid affectations that exacerbate the
severity and persistence of chronic pain. Specifically, depressive symptoms can lead to an …

Mood disorders such as depression and anxiety are frequently observed in patients
suffering from chronic pain. Over time, different tests and models have been developed in …

Recent studies have demonstrated that there are significant changes in the gut microbiota
(GM) of humans with depression and animal models of depression and chronic stress. In our …

Chronic pain is highly prevalent worldwide and represents a significant socioeconomic and
public health burden. Several aspects of chronic pain, for example back pain and a severity …

The midbrain dopamine center comprises a key network for reward, salience, motivation,
and mood. Evidence from various clinical and preclinical settings points to the midbrain …

N‐acetylcysteine, a sulphur‐containing amino acid for the treatment of paracetamol
overdose and chronic obstructive pulmonary disease, is a widely available off‐the‐shelf oral …

Chronic pain is a serious public health problem with a strong affective-motivational
component that makes it difficult to treat. Most patients with chronic pain suffer from severe …

Abstract Glucagon-like peptide 1 (GLP-1) receptor agonists are widely used for glycemic
control in patients with diabetes mellitus (DM) and are primarily indicated for type 2 diabetes …

A growing body of evidence from both clinical and animal studies indicates that chronic
neuropathic pain is associated with comorbid affective disorders. Spinal cord microglial …

Depression and anxiety commonly occur in chronic pain states and the coexistence of these
diseases worsens outcomes for both disorders and may reduce treatment adherence and …