CC chemokines, a subfamily of 27 chemotactic cytokines, are a component of intercellular
communication, which is crucial for the functioning of the tumor microenvironment. Although …

Head and neck squamous cell carcinomas (HNSCCs) are an aggressive, genetically
complex and difficult to treat group of cancers. In lieu of truly effective targeted therapies …

The communication between tumor-derived elements and stroma in the metastatic niche has
a critical role in facilitating cancer metastasis. Yet, the mechanisms tumor cells use to control …

Background Hepatocellular carcinoma (HCC) remains a global challenge due to its high
morbidity and mortality rates as well as poor response to treatment. The communication …

In malignant tumors, cancer cells adapt to grow within their host tissue. As a cancer
progresses, an accompanying host stromal response evolves within and around the nascent …

Tumours have developed strategies to interfere with most steps required for anti-tumour
immune responses. Although many populations contribute to anti-tumour responses, tumour …

Abstract In tumors, Cancer-Associated Fibroblasts (CAFs) constitute the most prominent
component of the tumor microenvironment (TME). CAFs are heterogeneous and composed …

Fibroblasts regulate the structure and function of healthy tissues, participate transiently in
tissue repair after acute inflammation, and assume an aberrant stimulatory role during …

The tumor microenvironment (TME) is comprised of many different cell populations, such as
cancer-associated fibroblasts and various infiltrating immune cells, and non-cell …

Extensive experimental evidence shows that platelets support tumour metastasis. The
activation of platelets and the coagulation system have a crucial role in the progression of …