The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

Pulmonary defense against environmental injury depends on airway mucus, which traps
inhaled toxins that are then cleared from the lungs by ciliary beating and cough. This review …

Cystic fibrosis (CF) is a fatal genetic disease caused by mutations in the gene encoding the
CF transmembrane conductance regulator (CFTR), a protein kinase A (PKA)-activated …

Calcium-activated chloride channels (CaCCs) are major regulators of sensory transduction,
epithelial secretion, and smooth muscle contraction. Other crucial roles of CaCCs include …

Normal airway mucus lines the epithelial surface and provides an important innate immune
function by detoxifying noxious molecules and by trapping and removing pathogens and …

Chronic lung disease determines the morbidity and mortality of cystic fibrosis (CF) patients.
The pulmonary immune response in CF is characterized by an early and non-resolving …

The lung must maintain a proper barrier between airspaces and fluid filled tissues in order to
maintain lung fluid balance. Central to maintaining lung fluid balance are epithelial cells …

Markedly upregulated production of MUC5AC together with stimulated secretion leads to
airflow obstruction in asthma. As MUC5B appears to mediate homeostatic functions, it may …

Delivering therapeutic agents to the lungs requires a deep understanding of the kinetics and
dynamics of drugs in this biologically and physiologically complex system. In this chapter …

Pf bacteriophage are temperate phages that infect the bacterium Pseudomonas aeruginosa,
a major cause of chronic lung infections in cystic fibrosis (CF) and other settings. Pf and …