Emerging epigenetic insights into aging mechanisms and interventions

Z Wu, W Zhang, J Qu, GH Liu - Trends in Pharmacological Sciences, 2024 - cell.com
Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although
still an evolving field with much to explore, it has rapidly gained significance by providing …

[HTML][HTML] Rethinking neurodegenerative diseases: neurometabolic concept linking lipid oxidation to diseases in the central nervous system

SS Helgudóttir, AS Mørkholt, J Lichota… - Neural Regeneration …, 2024 - journals.lww.com
Currently, there is a lack of effective medicines capable of halting or reversing the
progression of neurodegenerative disorders, including amyotrophic lateral sclerosis …

Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer's disease

MM Sonsalla, R Babygirija, M Johnson, S Cai, M Cole… - GeroScience, 2024 - Springer
Age is the greatest risk factor for Alzheimer's disease (AD) as well as for other disorders that
increase the risk of AD such as diabetes and obesity. There is growing interest in …

Mitochondrial transplants to treat mitochondrial dysfunction

A Bitto - Nature Metabolism, 2024 - nature.com
A new approach to treating mitochondrial disorders is based on the transplantation of
healthy mitochondria, and improves symptoms and survival in a mouse model of Leigh …

The Blood–Brain Barrier Is Unaffected in the Ndufs4−/− Mouse Model of Leigh Syndrome

R Reynaud-Dulaurier, R Clément, S Yjjou… - International Journal of …, 2024 - mdpi.com
Mitochondrial dysfunction plays a major role in physiological aging and in many
pathological conditions. Yet, no study has explored the consequence of primary …

The fountain of youth of mitochondrial research: Research is targeting mitochondrial dysfunction to tackle aging and much more, but hype is an increasing concern

A Rinaldi - EMBO reports, 2023 - embopress.org
Mitochondria in our cells take com-ponents from the food we eat and turn them into energy.
This essential role in energy metabolism is fundamental to the way cells work and the …

重新思考神经退行性疾病: 将脂质氧化与中枢神经系统疾病联系起来的神经代谢概念

SS Helgudóttir, AS Mørkholt, J Lichota… - 中国神经再生研究 …, 2024 - sjzsyj.com.cn
Currently, there is a lack of effective medicines capable of halting or reversing the
progression of neurodegenerative disorders, including amyotrophic lateral sclerosis …

[HTML][HTML] The fountain of youth of mitochondrial research

A Rinaldi - EMBO reports, 2023 - embopress.org
The fountain of youth of mitochondrial research: Research is targeting mitochondrial
dysfunction to tackle aging and much more, but hype is an increasing concern: EMBO reports …

Maltodextrin administration ameliorates brain pathology in a mouse model of mitochondrial disease

A Dominguez-Martinez, E Molina-Menor… - bioRxiv, 2023 - biorxiv.org
Mitochondrial dysfunction lead to a wide group of progressive and fatal pathologies known
as mitochondrial diseases (MD). One of the most common pediatric representation of MD is …