The tubulin code and its role in controlling microtubule properties and functions
C Janke, MM Magiera - Nature Reviews Molecular Cell Biology, 2020 - nature.com
Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, shaping, motility and intracellular transport. Despite their functional heterogeneity …
division, shaping, motility and intracellular transport. Despite their functional heterogeneity …
The tubulin code: molecular components, readout mechanisms, and functions
C Janke - Journal of Cell Biology, 2014 - rupress.org
Microtubules are cytoskeletal filaments that are dynamically assembled from α/β-tubulin
heterodimers. The primary sequence and structure of the tubulin proteins and, consequently …
heterodimers. The primary sequence and structure of the tubulin proteins and, consequently …
Regulation of microtubule motors by tubulin isotypes and post-translational modifications
M Sirajuddin, LM Rice, RD Vale - Nature cell biology, 2014 - nature.com
The 'tubulin-code'hypothesis proposes that different tubulin genes or post-translational
modifications (PTMs), which mainly confer variation in the carboxy-terminal tail (CTT), result …
modifications (PTMs), which mainly confer variation in the carboxy-terminal tail (CTT), result …
Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions
C Janke, J Chloë Bulinski - Nature reviews Molecular cell biology, 2011 - nature.com
Half a century of biochemical and biophysical experiments has provided attractive models
that may explain the diverse functions of microtubules within cells and organisms. However …
that may explain the diverse functions of microtubules within cells and organisms. However …
Tubulin polyglutamylation differentially regulates microtubule‐interacting proteins
M Genova, L Grycova, V Puttrich, MM Magiera… - The EMBO …, 2023 - embopress.org
Tubulin posttranslational modifications have been predicted to control cytoskeletal functions
by coordinating the molecular interactions between microtubules and their associating …
by coordinating the molecular interactions between microtubules and their associating …
Post-translational modifications regulate microtubule function
S Westermann, K Weber - Nature reviews Molecular cell biology, 2003 - nature.com
The αβ-tubulin heterodimer, the building block of microtubules, is subject to a large number
of post-translational modifications, comparable in diversity to the intensively studied histone …
of post-translational modifications, comparable in diversity to the intensively studied histone …
Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific beta-tubulin isotypes.
M Kavallaris, DY Kuo, CA Burkhart… - The Journal of …, 1997 - Am Soc Clin Investig
The treatment of advanced ovarian cancer with taxol is hindered by the development of drug
resistance. The cellular target for taxol is the microtubule that is stabilized by the drug. Taxol …
resistance. The cellular target for taxol is the microtubule that is stabilized by the drug. Taxol …
[HTML][HTML] A family of protein-deglutamylating enzymes associated with neurodegeneration
K Rogowski, J Van Dijk, MM Magiera, C Bosc… - Cell, 2010 - cell.com
Polyglutamylation is a posttranslational modification that generates glutamate side chains
on tubulins and other proteins. Although this modification has been shown to be reversible …
on tubulins and other proteins. Although this modification has been shown to be reversible …
Multiple forms of tubulin: different gene products and covalent modifications
RF Ludueña - International review of cytology, 1997 - Elsevier
Tubulin, the subunit protein of microtubules, is an α/β heterodimer. In many organisms, both
α and β exist in numerous isotypic forms encoded by different genes. In addition, both α and …
α and β exist in numerous isotypic forms encoded by different genes. In addition, both α and …
Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton
C Janke, M Kneussel - Trends in neurosciences, 2010 - cell.com
In the past decades, a range of post-translational modifications has been discovered on
tubulins, the major constituents of microtubules. Pioneering studies have described the …
tubulins, the major constituents of microtubules. Pioneering studies have described the …