Caught up in a Wnt storm: Wnt signaling in cancer
The Wnt signaling pathway, named for its most upstream ligands, the Wnts, is involved in
various differentiation events during embryonic development and leads to tumor formation …
various differentiation events during embryonic development and leads to tumor formation …
Linking colorectal cancer to Wnt signaling
Tumors of the colorectum are amongst the most comof the new discoveries that are relevant
to colorectal mon human neoplasms. Approximately 5% of the Westcancer in humans have …
to colorectal mon human neoplasms. Approximately 5% of the Westcancer in humans have …
Functional interaction of β-catenin with the transcription factor LEF-1
THE cytoplasmic proteins β-catenin of vertebrates and armadillo of Drosophila have two
functions: they link the cadherin cell-adhesion molecules to the cytoskeleton1–4, and they …
functions: they link the cadherin cell-adhesion molecules to the cytoskeleton1–4, and they …
XTcf-3 transcription factor mediates β-catenin-induced axis formation in Xenopus embryos
M Molenaar, M Van De Wetering, M Oosterwegel… - Cell, 1996 - cell.com
XTcf-3 is a maternally expressed Xenopus homolog of the mammalian HMG box factors Tcf-
1 and Lef-1. The N-terminus of XTcf-3 binds to β-catenin. Microinjection of XTcf-3 mRNA in …
1 and Lef-1. The N-terminus of XTcf-3 binds to β-catenin. Microinjection of XTcf-3 mRNA in …
SOX9 directly regulates the type-ll collagen gene
DM Bell, KKH Leung, SC Wheatley, LJ Ng, S Zhou… - Nature …, 1997 - nature.com
Mutations in human SOX9 are associated with campomelic dysplasia (CD), characterised by
skeletal malformation and XY sex reversal1–3. During chondrogenesis in the mouse, Sox9 …
skeletal malformation and XY sex reversal1–3. During chondrogenesis in the mouse, Sox9 …
Wnt signaling in osteoblasts and bone diseases
JJ Westendorf, RA Kahler, TM Schroeder - Gene, 2004 - Elsevier
Recent revelations that the canonical Wnt signaling pathway promotes postnatal bone
accrual are major advances in our understanding of skeletal biology and bring tremendous …
accrual are major advances in our understanding of skeletal biology and bring tremendous …
Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.
C van Genderen, RM Okamura, I Farinas… - Genes & …, 1994 - genesdev.cshlp.org
Lymphoid enhancer factor 1 (LEF-1) is a sequence-specific DNA-binding protein that is
expressed in pre-B and T lymphocytes of adult mice, and in the neural crest …
expressed in pre-B and T lymphocytes of adult mice, and in the neural crest …
Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3.
Fibroblast growth factor 4 (FGF-4) has been shown to be a signaling molecule whose
expression is essential for postimplantation mouse development and, at later embryonic …
expression is essential for postimplantation mouse development and, at later embryonic …
SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse
LJ Ng, S Wheatley, GEO Muscat… - Developmental …, 1997 - Elsevier
Two lines of evidence suggest that theSry-related geneSox9is important for chondrogenesis
in mammalian embryos. Sox9mRNA is expressed in chondrogenic condensations in mice …
in mammalian embryos. Sox9mRNA is expressed in chondrogenic condensations in mice …
Diversity of LEF/TCF action in development and disease
L Arce, NN Yokoyama, ML Waterman - Oncogene, 2006 - nature.com
Lymphoid enhancer factor/T cell factor proteins (LEF/TCFs) mediate Wnt signals in the
nucleus by recruiting β-catenin and its co-activators to Wnt response elements (WREs) of …
nucleus by recruiting β-catenin and its co-activators to Wnt response elements (WREs) of …