Chronic inflammation has long been recognized as a risk factor for human cancer at various
sites. Examples include Helicobacter pylori-induced gastritis for gastric cancer, inflammatory …

The authors review studies on 8-nitroguanine (8-NO2-G) formed by reactions of guanine,
guanosine, and 2́-deoxyguanosine, either free or in DNA or RNAwith reactive nitrogen …

In living tissues under inflammatory conditions, superoxide radicals (O 2−⋅) are generated
and are known to cause oxidative DNA damage. However, the mechanisms of action are …

Page 1 Page 2 Topics in Applied Chemistry For other titles published in this series, go to
www.springer.com/series/6610 Page 3 Lyudmila Larina • Valentin Lopyrev Nitroazoles …

The exposure of guanine in the oligonucleotide 5′-d (TCGCT) to one-electron oxidants
leads initially to the formation of the guanine radical cation G•+, its deptotonation product G …

It is generally believed that the mammalian nucleotide excision repair pathway removes
DNA helix-distorting bulky DNA lesions, while small non-bulky lesions are repaired by base …

The well known biomarker of oxidative stress, 8-oxo-7, 8-dihydroguanine, is more
susceptible to further oxidation than the parent guanine base and can be oxidatively …

DNA damage by endogenous and exogenous agents is a serious concern, as the damaged
products can affect genome integrity severely. Damage to DNA may arise from various …

Small GTPases, including the proto-oncoprotein Ras and Rho GTPases, are involved in
various cellular signaling events. Some of these small GTPases are redox sensitive …

8-Nitro-2 '-deoxyguanosine (8-NO2-dG) DNA adducts are induced by the reactive nitrogen
species and may be associated with the development of cancer in inflammatory tissues. To …