Training vs. Tolerance: the yin/yang of the innate immune system
For almost nearly a century, memory functions have been attributed only to acquired
immune cells. Lately, this paradigm has been challenged by an increasing number of …
immune cells. Lately, this paradigm has been challenged by an increasing number of …
Gut microbiota-derived small extracellular vesicles endorse memory-like inflammatory responses in murine neutrophils
T Lajqi, N Köstlin-Gille, S Hillmer, M Braun, SA Kranig… - Biomedicines, 2022 - mdpi.com
Neutrophils are classically characterized as merely reactive innate effector cells. However,
the microbiome is known to shape the education and maturation process of neutrophils …
the microbiome is known to shape the education and maturation process of neutrophils …
LPS induces opposing memory-like inflammatory responses in mouse bone marrow neutrophils
T Lajqi, M Braun, SA Kranig, D Frommhold… - International journal of …, 2021 - mdpi.com
A growing body of evidence suggests that innate immune cells can respond in a memory-
like (adaptive) fashion, which is referred to as trained immunity. Only few in vivo studies …
like (adaptive) fashion, which is referred to as trained immunity. Only few in vivo studies …
Gram-positive Staphylococcus aureus LTA promotes distinct memory-like effects in murine bone marrow neutrophils
T Lajqi, D Frommhold, M Braun, SA Kranig, J Pöschl… - Cellular …, 2022 - Elsevier
Neutrophils primarily act as first responders in acute infection and directly maintain
inflammatory responses. However, a growing body of evidence suggests that neutrophils …
inflammatory responses. However, a growing body of evidence suggests that neutrophils …