Size is a fundamental attribute impacting cellular design, fitness, and function. Size
homeostasis requires a doubling of cell mass with each division. In yeast, division is delayed …

The cyclin dependent kinase Cdk1 controls the cell cycle, which is best understood in the
model organism S. cerevisiae. Research performed during the past decade has significantly …

Many disease states result from gene overexpression, often in a specific genetic context. To
explore gene overexpression phenotypes systematically, we assembled an array of 5280 …

Cell size is an important adaptive trait that influences nearly all aspects of cellular
physiology. Despite extensive characterization of the cell-cycle regulatory network, the …

Cell-size homeostasis entails a fundamental balance between growth and division. The
budding yeast Saccharomyces cerevisiae establishes this balance by enforcing growth to a …

In budding yeast, Saccharomyces cerevisiae, the Start checkpoint integrates multiple
internal and external signals into an all-or-none decision to enter the cell cycle. Here we …

Cells of a given type maintain a characteristic cell size to function efficiently in their
ecological or organismal context. They achieve this through the regulation of growth rates or …

Budding yeast cells are assumed to trigger Start and enter the cell cycle only after they attain
a critical size set by external conditions. However, arguing against deterministic models of …

In the budding yeast, Saccharomyces cerevisiae, a significant fraction of genes (> 10%) are
transcribed with cell cycle periodicity. These genes encode critical cell cycle regulators as …

The molecular networks regulating the G1–S transition in budding yeast and mammals are
strikingly similar in network structure. However, many of the individual proteins performing …