Specific cell states in metazoans are established by the symphony of gene expression
programs that necessitate intricate synergic interactions between transcription factors and …

Ferroptosis is a form of cell death mediated by iron and lipid peroxidation (LPO). Recent
studies have provided compelling evidence to support the involvement of ferroptosis in the …

Lung adenocarcinoma (LUAD) and small cell lung cancer (SCLC) are thought to originate
from different epithelial cell types in the lung. Intriguingly, LUAD can histologically transform …

The transcription factor MYCN is frequently amplified and overexpressed in a variety of
cancers including high-risk neuroblastoma (NB) and promotes tumor cell proliferation …

Regarding the multimechanistic nature of cancers, current chemo‐or radiotherapies often
fail to eradicate disease pathology, and frequent relapses or resistance to therapies occur …

Metastasis is a major cause of morbidity and mortality in patients with cancer, highlighting
the need to identify improved treatment and prevention strategies. Previous observations in …

Dear Editor, Emerging evidence supports that ASXL1 mutation in myeloid neoplasia leads to
aberrant protein gain-of-function rather than loss-of-function as initially thought [1]. Thus, a …

Mutations in BAP1 have been identified in a hereditary cancer predisposition syndrome and
in sporadic tumours. Individuals carrying familiar BAP1 monoallelic mutations display …

Although sex differences have been reported in patients with clear cell renal cell carcinoma
(ccRCC), biological sex has not received clinical attention and genetic differences between …

Ubiquitination is a type of post-translational modification that covalently links ubiquitin to a
target protein, which plays a critical role in modulating protein activity, stability, and …