Extracellular matrix in the trabecular meshwork: intraocular pressure regulation and dysregulation in glaucoma
The trabecular meshwork (TM) is located in the anterior segment of the eye and is
responsible for regulating the outflow of aqueous humor. Increased resistance to aqueous …
responsible for regulating the outflow of aqueous humor. Increased resistance to aqueous …
[HTML][HTML] Aqueous outflow-A continuum from trabecular meshwork to episcleral veins
T Carreon, E van der Merwe, RL Fellman… - Progress in retinal and …, 2017 - Elsevier
In glaucoma, lowered intraocular pressure (IOP) confers neuroprotection. Elevated IOP
characterizes glaucoma and arises from impaired aqueous humor (AH) outflow. Increased …
characterizes glaucoma and arises from impaired aqueous humor (AH) outflow. Increased …
Pathogenesis of glaucoma: Extracellular matrix dysfunction in the trabecular meshwork‐A review
KE Keller, DM Peters - Clinical & experimental ophthalmology, 2022 - Wiley Online Library
The trabecular meshwork regulates aqueous humour outflow from the anterior chamber of
the eye. It does this by establishing a tunable outflow resistance, defined by the interplay …
the eye. It does this by establishing a tunable outflow resistance, defined by the interplay …
[HTML][HTML] Netarsudil increases outflow facility in human eyes through multiple mechanisms
R Ren, G Li, TD Le, C Kopczynski… - … & visual science, 2016 - jov.arvojournals.org
Purpose: Netarsudil is a Rho kinase/norepinephrine transporter inhibitor currently in phase
3 clinical development for glaucoma treatment. We investigated the effects of its active …
3 clinical development for glaucoma treatment. We investigated the effects of its active …
Trabecular meshwork stiffness in glaucoma
Alterations in stiffness of the trabecular meshwork (TM) may play an important role in primary
open-angle glaucoma (POAG), the second leading cause of blindness. Specifically, certain …
open-angle glaucoma (POAG), the second leading cause of blindness. Specifically, certain …
Biomechanics of Schlemm's canal endothelium and intraocular pressure reduction
Ocular hypertension in glaucoma develops due to age-related cellular dysfunction in the
conventional outflow tract, resulting in increased resistance to aqueous humor outflow. Two …
conventional outflow tract, resulting in increased resistance to aqueous humor outflow. Two …
Intraocular pressure homeostasis: maintaining balance in a high-pressure environment
Although glaucoma is a relatively common blinding disease, most people do not develop
glaucoma. A robust intraocular pressure (IOP) homeostatic mechanism keeps ocular …
glaucoma. A robust intraocular pressure (IOP) homeostatic mechanism keeps ocular …
[HTML][HTML] The trabecular meshwork: a basic review of form and function
Background Glaucoma is a group of optic neuropathies in which damage to the optic nerve
results in a distinctive pattern of irreversible vision loss. Elevations in the intraocular …
results in a distinctive pattern of irreversible vision loss. Elevations in the intraocular …
Variations in active outflow along the trabecular outflow pathway
Previous tracer studies have shown segmental outflow in the trabecular meshwork (TM) and
along the inner wall (IW) of Schlemm's canal (SC). Whether segmental outflow is conserved …
along the inner wall (IW) of Schlemm's canal (SC). Whether segmental outflow is conserved …
Aqueous angiographic outflow improvement after trabecular microbypass in glaucoma patients
AS Huang, RC Penteado, V Papoyan… - Ophthalmology …, 2019 - Elsevier
Purpose To study changes in aqueous humor outflow (AHO) patterns after trabecular
microbypass (TMB) in glaucoma patients using intraoperative sequential aqueous …
microbypass (TMB) in glaucoma patients using intraoperative sequential aqueous …