Macrophages in intestinal homeostasis and inflammatory bowel disease
LM Hegarty, GR Jones, CC Bain - Nature Reviews Gastroenterology & …, 2023 - nature.com
Macrophages are essential for the maintenance of intestinal homeostasis, yet appear to be
drivers of inflammation in the context of inflammatory bowel disease (IBD). How these …
drivers of inflammation in the context of inflammatory bowel disease (IBD). How these …
Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD
Macrophages are the gatekeepers of intestinal immune homeostasis as they discriminate
between innocuous antigens and potential pathogens to maintain oral tolerance. However …
between innocuous antigens and potential pathogens to maintain oral tolerance. However …
Cross-tissue immune cell analysis reveals tissue-specific features in humans
C Domínguez Conde, C Xu, LB Jarvis, DB Rainbow… - Science, 2022 - science.org
Despite their crucial role in health and disease, our knowledge of immune cells within
human tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 …
human tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 …
[HTML][HTML] Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease
A Garrido-Trigo, AM Corraliza, M Veny, I Dotti… - Nature …, 2023 - nature.com
Ulcerative colitis and Crohn's disease are chronic inflammatory intestinal diseases with
perplexing heterogeneity in disease manifestation and response to treatment. While the …
perplexing heterogeneity in disease manifestation and response to treatment. While the …
[HTML][HTML] The short chain fatty acid butyrate imprints an antimicrobial program in macrophages
J Schulthess, S Pandey, M Capitani, KC Rue-Albrecht… - Immunity, 2019 - cell.com
Host microbial cross-talk is essential to maintain intestinal homeostasis. However,
maladaptation of this response through microbial dysbiosis or defective host defense toward …
maladaptation of this response through microbial dysbiosis or defective host defense toward …
[HTML][HTML] Tissue-resident immune cells in humans
Tissue-resident immune cells span both myeloid and lymphoid cell lineages, have been
found in multiple human tissues, and play integral roles at all stages of the immune …
found in multiple human tissues, and play integral roles at all stages of the immune …
Macrophages in the gut: Masters in multitasking
M Delfini, N Stakenborg, MF Viola, G Boeckxstaens - Immunity, 2022 - cell.com
The gastrointestinal tract has the important task of absorbing nutrients, a complex process
that requires an intact barrier allowing the passage of nutrients but that simultaneously …
that requires an intact barrier allowing the passage of nutrients but that simultaneously …
Monocytes, macrophages, dendritic cells and neutrophils: an update on lifespan kinetics in health and disease
Phagocytes form a family of immune cells that play a crucial role in tissue maintenance and
help orchestrate the immune response. This family of cells can be separated by their nuclear …
help orchestrate the immune response. This family of cells can be separated by their nuclear …
[HTML][HTML] Origin, differentiation, and function of intestinal macrophages
CC Bain, A Schridde - Frontiers in immunology, 2018 - frontiersin.org
Macrophages are increasingly recognized as essential players in the maintenance of
intestinal homeostasis and as key sentinels of the intestinal immune system. However …
intestinal homeostasis and as key sentinels of the intestinal immune system. However …
[HTML][HTML] In vivo Differentiation of Human Monocytes
A Coillard, E Segura - Frontiers in immunology, 2019 - frontiersin.org
Circulating monocytes can infiltrate mucosal or inflamed tissues where they differentiate into
either macrophages or dendritic cells. This paradigm is supported by numerous studies …
either macrophages or dendritic cells. This paradigm is supported by numerous studies …