Neurodegenerative disorders, such as Alzheimer's disease, are a global public health
burden with poorly understood aetiology. Neuroinflammation and oxidative stress (OS) are …

Microglia are activated in response to a number of different pathological states within the
CNS including injury, ischemia, and infection. Microglial activation results in their production …

Little is known about the mechanisms converting psychosocial stress into cellular
dysfunction. Various genes, up-regulated in atherosclerosis but also by psychosocial stress …

The signal transduction pathways activated by the proinflammatory cytokine interleukin-1 (IL-
1) have been the focus of much attention because of the important role that IL-1 plays in …

The phenomenon of endotoxin tolerance has been widely investigated, but to date, the
molecular mechanisms of endotoxin tolerance remain to be resolved clearly. The discovery …

Toll-like receptors (TLR) and NOD2 are emerging as key mediators of innate host defence in
the intestinal mucosa, crucially involved in maintaining mucosal as well as commensal …

Abstract Integration of Hepatitis B Virus (HBV) DNA into liver cell DNA has been well
established, but its implication in liver carcinogenesis is still being debated. In particular …

Abstract Aims Angiotensin II (AngII) is involved in extracellular matrix (ECM) accumulation
contributing to heart failure. Periostin, a 90 kDa ECM protein, is a key regulator of cardiac …

Cancer could be deemed as an abnormal and uncontrolled tissue repair process. Therefore,
it would not be surprising that factors that function in the tissue repair process, such as …

Embryonic stem cells have the distinct potential for tissue regeneration, including cardiac
repair. Their propensity for multilineage differentiation carries, however, the liability of …