The secondary metabolites of rare actinomycetes: chemistry and bioactivity
T Ding, LJ Yang, WD Zhang, YH Shen - RSC advances, 2019 - pubs.rsc.org
Actinomycetes are outstanding and fascinating sources of potent bioactive compounds,
particularly antibiotics. In recent years, rare actinomycetes have had an increasingly …
particularly antibiotics. In recent years, rare actinomycetes have had an increasingly …
Discovery of novel secondary metabolites encoded in actinomycete genomes through coculture
Actinomycetes are a rich source of bioactive natural products important for novel drug leads.
Recent genome mining approaches have revealed an enormous number of secondary …
Recent genome mining approaches have revealed an enormous number of secondary …
Genomic and spectroscopic signature-based discovery of natural macrolactams
The logical and effective discovery of macrolactams, structurally unique natural molecules
with diverse biological activities, has been limited by a lack of targeted search methods …
with diverse biological activities, has been limited by a lack of targeted search methods …
Utilizing cross-species co-cultures for discovery of novel natural products
Highlights•Cross-species co-cultures can be used to activate cryptic genes' expression for
biosynthesis of novel natural products.•A variety of co-cultivation methods have been …
biosynthesis of novel natural products.•A variety of co-cultivation methods have been …
Activation of silent biosynthetic pathways and discovery of novel secondary metabolites in actinomycetes by co-culture with mycolic acid-containing bacteria
Bacterial secondary metabolites (SM) are rich sources of drug leads, and in particular,
numerous metabolites have been isolated from actinomycetes. It was revealed by recent …
numerous metabolites have been isolated from actinomycetes. It was revealed by recent …
Renewed interests in the discovery of bioactive actinomycete metabolites driven by emerging technologies
Actinomycetes are prolific sources of bioactive molecules. Traditional workflows including
bacterial isolation, fermentation, metabolite identification and structure elucidation have …
bacterial isolation, fermentation, metabolite identification and structure elucidation have …
Elicitation for activation of the actinomycete genome's cryptic secondary metabolite gene clusters
SS El-Hawary, MHA Hassan, AO Hudhud… - RSC …, 2023 - pubs.rsc.org
This review summarizes the recent advances in the elicitation approaches used to activate
the actinomycete genome's cryptic secondary metabolite gene clusters and shows the …
the actinomycete genome's cryptic secondary metabolite gene clusters and shows the …
An isotopic labeling approach linking natural products with biosynthetic gene clusters
CS McCaughey, JA van Santen… - Nature chemical …, 2022 - nature.com
Major advances in genome sequencing and large-scale biosynthetic gene cluster (BGC)
analysis have prompted an age of natural product discovery driven by genome mining. Still …
analysis have prompted an age of natural product discovery driven by genome mining. Still …
Natural polyenic macrolactams and polycyclic derivatives generated by transannular pericyclic reactions: optimized biogenesis challenging chemical synthesis
R Alvarez, AR de Lera - Natural Product Reports, 2021 - pubs.rsc.org
Covering from 1992 to the end of 2020-11-20. Genetically-encoded polyenic macrolactams,
which are constructed by Nature using hybrid polyketide synthase/nonribosomal peptide …
which are constructed by Nature using hybrid polyketide synthase/nonribosomal peptide …
Structural characterization and SARS-CoV-2 inhibitory effects of alkaloids from the roots of Asarum heterotropoides var. mandshuricum (Aristolochiaceae)
Asarum heterotropoides var. mandshuricum F. Maekawa (Aristolochiaceae), well-known as
“Marchurian Wildginger”, shows many bioactivities that contribute to its therapeutic effects …
“Marchurian Wildginger”, shows many bioactivities that contribute to its therapeutic effects …