Maladaptive plasticity in tinnitus—triggers, mechanisms and treatment

SE Shore, LE Roberts, B Langguth - Nature Reviews Neurology, 2016 - nature.com
Tinnitus is a phantom auditory sensation that reduces quality of life for millions of people
worldwide, and for which there is no medical cure. Most cases of tinnitus are associated with …

What's the buzz? The neuroscience and the treatment of tinnitus

A Henton, T Tzounopoulos - Physiological reviews, 2021 - journals.physiology.org
Tinnitus is a pervasive public health issue that affects∼ 15% of the United States population.
Similar estimates have also been shown on a global scale, with similar prevalence found in …

Why is there no cure for tinnitus?

DJ McFerran, D Stockdale, R Holme… - Frontiers in …, 2019 - frontiersin.org
Tinnitus is unusual for such a common symptom in that there are few treatment options and
those that are available are aimed at reducing the impact rather than specifically addressing …

Animal models of tinnitus

TJ Brozoski, CA Bauer - Hearing research, 2016 - Elsevier
Presented is a thematic review of animal tinnitus models from a functional perspective.
Chronic tinnitus is a persistent subjective sound sensation, emergent typically after hearing …

Behavioral models of tinnitus and hyperacusis in animals

SH Hayes, KE Radziwon, DJ Stolzberg… - Frontiers in …, 2014 - frontiersin.org
The phantom perception of tinnitus and reduced sound-level tolerance associated with
hyperacusis have a high comorbidity and can be debilitating conditions for which there are …

Use of the guinea pig in studies on the development and prevention of acquired sensorineural hearing loss, with an emphasis on noise

G Naert, MP Pasdelou, CG Le Prell - The Journal of the Acoustical …, 2019 - pubs.aip.org
Stebbins et al.(1982) suggested the guinea pig to be one of the most useful species in which
to assess the effects of noise on the inner ear based on overlap with the audible frequency …

[HTML][HTML] Regulation of auditory plasticity during critical periods and following hearing loss

D Persic, ME Thomas, V Pelekanos, DK Ryugo… - Hearing research, 2020 - Elsevier
Sensory input has profound effects on neuronal organization and sensory maps in the brain.
The mechanisms regulating plasticity of the auditory pathway have been revealed by …

[HTML][HTML] The cerebellar (para) flocculus: A review on its auditory function and a possible role in tinnitus

LM Mennink, JMC van Dijk, P van Dijk - Hearing research, 2020 - Elsevier
The cerebellum is historically considered to be involved in motor control and motor learning.
However, it is also a site of multimodal sensory and sensory-motor integration, implicated in …

[HTML][HTML] Pharmacologic treatments in preclinical tinnitus models with special focus on Ginkgo biloba leaf extract EGb 761®

SW Barth, MD Lehner, GPH Dietz, H Schulze - Molecular and Cellular …, 2021 - Elsevier
Tinnitus is defined as the perception of sound in the absence of external acoustic stimuli.
Frequent comorbidities or associated factors are depression, anxiety, concentration …

A new statistical approach for the evaluation of gap-prepulse inhibition of the acoustic startle reflex (GPIAS) for tinnitus assessment

A Schilling, P Krauss, R Gerum, C Metzner… - Frontiers in behavioral …, 2017 - frontiersin.org
Background: An increasingly used behavioral paradigm for the objective assessment of a
possible tinnitus percept in animal models has been proposed by Turner and coworkers in …