The members of the Tear Film Subcommittee reviewed the role of the tear film in dry eye
disease (DED). The Subcommittee reviewed biophysical and biochemical aspects of tears …

Abstract The TFOS DEWS II Pathophysiology Subcommittee reviewed the mechanisms
involved in the initiation and perpetuation of dry eye disease. Its central mechanism is …

Pain associated with mechanical, chemical, and thermal heat stimulation of the ocular
surface is mediated by trigeminal ganglion neurons, while cold thermoreceptors detect …

Great strides have recently been made in quantitative measurements of tear film thickness
and thinning, mathematical modeling thereof and linking these to sensory perception. This …

Dry eye disease (DED) affects. 10% of the population worldwide, and it provokes an
unpleasant sensation of ocular dryness, whose underlying neural mechanisms remain …

The precorneal tear film is maintained by blinking and exhibits different phases in the tear
cycle. The tear film serves as the most anterior surface of the eye and plays an important role …

Eye irritation, for example dry or irritated eyes, is generally among top three reported
symptoms in office‐like environments, in particular among workplaces with cognitive …

Blink is a complex phenomenon that is profoundly affected by diverse endogenous and
exogenous stimuli. It has been studied in the context of cognition, emotional, and …

Tear film breakup (BU) is an important aspect of dry eye disease, as a cause of ocular
aberrations, irritation and ocular surface inflammation and disorder. Additionally …

Dry eye disease (DED) is a multifactorial disease of the tears and ocular surface that causes
tear film instability with potential damage to the ocular surface. The prevalence of dry eye in …