The genetic dissection of major depressive disorder (MDD) ranks as one of the success
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …

The kynurenine pathway (KP) plays a critical role in generating cellular energy in the form of
nicotinamide adenine dinucleotide (NAD+). Because energy requirements are substantially …

Objectives: To provide advice and guidance regarding the management of mood disorders,
derived from scientific evidence and supplemented by expert clinical consensus to formulate …

Chronic psychosocial stress increases disease risk and mortality, but the underlying
mechanisms remain largely unclear. Here we outline an energy-based model for the …

An estimated 50% of depressed patients are inadequately treated by available interventions.
Even with an eventual recovery, many patients require a trial and error approach, as there …

The assembly of DNA sequence data is undergoing a renaissance thanks to emerging
technologies capable of producing reads tens of kilobases long. Assembling complete …

Major depressive disorder (MDD), one of the most frequently encountered forms of mental
illness and a leading cause of disability worldwide, poses a major challenge to genetic …

Objective Mitochondria are multifunctional life-sustaining organelles that represent a
potential intersection point between psychosocial experiences and biological stress …

There is growing scientific interest to develop scalable biological measures that capture
mitochondrial (dys) function. Mitochondria have their own genome, the mitochondrial DNA …

Early adversity, in the form of abuse, neglect, socioeconomic status and other adverse
experiences, is associated with poor physical and mental health outcomes. To understand …