Highlights•Non-alcoholic steatohepatitis (NASH) is a medical disease of unmet therapeutic
need.•Numerous drugs are in various stages of clinical development for …

The endocannabinoid system (ECS) is one of the most crucial systems in the human
organism, exhibiting multi-purpose regulatory character. It is engaged in a vast array of …

Lysophosphatidylcholine (LPC) is an essential mediator in human lipid metabolism and is
associated with a variety of diseases, but the exact identity of LPC receptors remains …

Diabetes, a metabolic disease caused by abnormally high levels of blood glucose, has a
high prevalence rate worldwide and causes a series of complications, including coronary …

Alcohol use disorder (AUD) is a chronic relapsing condition characterized by compulsive
alcohol-seeking behaviors, with serious detrimental health consequences. Despite high …

There is growing evidence that glucose metabolism in the liver is in part under the control of
the endocannabinoid system (ECS) which is also supported by its presence in this organ …

Magnolol (MG) is the main active compound of Magnolia officinalis and exerts a wide range
of biological activities. In this study, we investigated the effects of MG using tyloxapol (Tylo) …

GPR119 belongs to the G protein‐coupled receptor family and exhibits dual modes of action
upon ligand‐dependent activation: pancreatic secretion of insulin in a glucose‐dependent …

In the past decade, G protein-coupled receptors have emerged as drug targets, and their
physiological and pathological effects have been extensively studied. Among these …

The pharmacological activation of G-protein coupled receptor-119 (GPR119) modulates
glucose, energy, and hepatic lipid homeostasis in type-2 diabetes (T2D). We developed …