Autophagy is a cell self-digestion pathway through lysosome and plays a critical role in
maintaining cellular homeostasis and cytoprotection. Characterization of autophagy related …

Whereas autism spectrum disorder (ASD) exhibits striking heterogeneity in genetics and
clinical presentation, dysfunction of mechanistic target of rapamycin complex 1 (mTORC1) …

The Reelin–DAB1 signaling pathway plays a crucial role in regulating neuronal migration
and synapse function. Although many rare heterozygous variants in the Reelin gene (RELN) …

We previously developed a lymphoblastoid cell line (LCL) model of mitochondrial
dysfunction in autism spectrum disorder (ASD); some individuals with ASD showed …

Several lines of indirect evidence, such as mutations or dysregulated expression of genes
related to cytoskeleton, have suggested that cytoskeletal dynamics, a process essential for …

Autism spectrum disorder (ASD) is a brain disorder that involves changes in neuronal
connections. Abnormal morphology of dendritic spines on postsynaptic neurons has been …

Protein synthesis regulation via mammalian target of rapamycin complex 1 (mTORC1)
signaling pathway has key roles in neural development and function, and its dysregulation is …

In recent years, accumulating evidence has shown that the innate immune complement
system is involved in several aspects of normal brain development and in …

Brain-derived neurotrophic factor (BDNF), a key peptide in neurocognitive development, has
been reported to be elevated in the serum of children with autism spectrum disorder (ASD) …

Cortical organoids derived from human induced pluripotent stem cells (hiPSCs) represent a
powerful in vitro experimental system to investigate human brain development and disease …