Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.

D Rice, S Barone Jr - Environmental health perspectives, 2000 - ehp.niehs.nih.gov
Vulnerable periods during the development of the nervous system are sensitive to
environmental insults because they are dependent on the temporal and regional emergence …

GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations

Y Ben-Ari, JL Gaiarsa, R Tyzio… - Physiological …, 2007 - journals.physiology.org
Developing networks follow common rules to shift from silent cells to coactive networks that
operate via thousands of synapses. This review deals with some of these rules and in …

Vascular niche for adult hippocampal neurogenesis

TD Palmer, AR Willhoite… - Journal of Comparative …, 2000 - Wiley Online Library
The thin lamina between the hippocampal hilus and granule cell layer, or subgranule zone
(SGZ), is an area of active proliferation within the adult hippocampus known to generate new …

Is there more to GABA than synaptic inhibition?

DF Owens, AR Kriegstein - Nature Reviews Neuroscience, 2002 - nature.com
In the mature brain, GABA (γ-aminobutyric acid) functions primarily as an inhibitory
neurotransmitter. But it can also act as a trophic factor during nervous system development …

Evidence that brain‐derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the …

J Lee, W Duan, MP Mattson - Journal of neurochemistry, 2002 - Wiley Online Library
To determine the role of brain‐derived neurotrophic factor (BDNF) in the enhancement of
hippocampal neurogenesis resulting from dietary restriction (DR), heterozygous BDNF …

Dopamine depletion impairs precursor cell proliferation in Parkinson disease

GU Höglinger, P Rizk, MP Muriel, C Duyckaerts… - Nature …, 2004 - nature.com
Cerebral dopamine depletion is the hallmark of Parkinson disease. Because dopamine
modulates ontogenetic neurogenesis, depletion of dopamine might affect neural precursors …

Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague–Dawley rats in vivo

J Farmer, XV Zhao, H Van Praag, K Wodtke, FH Gage… - Neuroscience, 2004 - Elsevier
We have previously shown that voluntary exercise produces enhanced neurogenesis and
long-term potentiation (LTP) in the dentate gyrus (DG) of mice in vitro. In the present …

Glutamate and neurotrophic factors in neuronal plasticity and disease

MP Mattson - Annals of the New York Academy of Sciences, 2008 - Wiley Online Library
Glutamate's role as a neurotransmitter at synapses has been known for 40 years, but
glutamate has since been shown to regulate neurogenesis, neurite outgrowth …

[HTML][HTML] Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical stem cells

X Qian, Q Shen, SK Goderie, W He, A Capela… - Neuron, 2000 - cell.com
Multipotent stem cells that generate both neurons and glia are widespread components of
the early neuroepithelium. During CNS development, neurogenesis largely precedes …

Induction of neurogenesis in the neocortex of adult mice

SS Magavi, BR Leavitt, JD Macklis - Nature, 2000 - nature.com
Neurogenesis normally only occurs in limited areas of the adult mammalian brain—the
hippocampus, olfactory bulb,, and epithelium, and at low levels in some regions of macaque …