Directing the differentiation of induced pluripotent stem cells into motor neurons has allowed
investigators to develop new models of amyotrophic lateral sclerosis (ALS). However …

Central nervous system (CNS) development, homeostasis, stress responses, and plasticity
are all mediated by epigenetic mechanisms that modulate gene expression and promote …

Stroke is an age-related disease. Recovery after stroke is associated with axonal sprouting
in cortex adjacent to the infarct. The molecular program that induces a mature cortical …

Stroke is the leading cause of adult disability. Yet there is a limited degree of recovery in this
disease. One of the mechanisms of recovery is the formation of new connections in the brain …

Chronic pain is a common neurological disease involving lasting, multifaceted
maladaptations ranging from gene modulation to synaptic dysfunction and emotional …

Epigenetic modifications help orchestrate sweeping developmental, aging, and disease-
causing changes in phenotype by altering transcriptional activity in multiple genes spanning …

BACKGROUND: Neurons containing proopiomelanocortin (POMC)-derived peptides, known
to control stress axis, metabolic, and immune functions, have a lower function in patients …

Simple Summary DNA methylation is an epigenetic modification of genes which affects
corresponding gene expression. During the developmental stage, embryonic stem cells …

The molecular mechanism of how the histone deacetylase HDA6 participates in maintaining
transposable element (TE) silencing in Arabidopsis (Arabidopsis thaliana) is not yet defined …

Background Prenatal exposure to ethanol (E t OH) reduces the expression of hypothalamic
proopiomelanocortin (POMC) gene, known to control various physiological functions …