The magic of bicelles lights up membrane protein structure

UHN Dürr, M Gildenberg, A Ramamoorthy - Chemical reviews, 2012 - ACS Publications
Biological membranes and membrane proteins, responsible for numerous exciting
biological processes, present one of the paramount challenges in biophysics today …

Myelin management by the 18.5‐kDa and 21.5‐kDa classic myelin basic protein isoforms

G Harauz, JM Boggs - Journal of neurochemistry, 2013 - Wiley Online Library
The classic myelin basic protein (MBP) splice isoforms range in nominal molecular mass
from 14 to 21.5 kDa, and arise from the gene in the oligodendrocyte lineage (Golli) in …

MyelStones: the executive roles of myelin basic protein in myelin assembly and destabilization in multiple sclerosis

KA Vassall, VV Bamm, G Harauz - Biochemical Journal, 2015 - portlandpress.com
The classic isoforms of myelin basic protein (MBP, 14–21.5 kDa) are essential to formation
of the multilamellar myelin sheath of the mammalian central nervous system (CNS). The …

Membrane association landscape of myelin basic protein portrays formation of the myelin major dense line

A Raasakka, S Ruskamo, J Kowal, R Barker… - Scientific reports, 2017 - nature.com
Compact myelin comprises most of the dry weight of myelin, and its insulative nature is the
basis for saltatory conduction of nerve impulses. The major dense line (MDL) is a 3-nm …

Intrinsic disorder as a natural preservative: high levels of intrinsic disorder in proteins found in the 2600-year-old human brain

AS Mohammed, VN Uversky - Biology, 2022 - mdpi.com
Simple Summary Reported earlier, results of the proteomic analysis of the Heslington brain
(which is at least 2600-year-old brain tissue uncovered within the skull excavated in 2008 …

Proton detection for signal enhancement in solid-state NMR experiments on mobile species in membrane proteins

ME Ward, E Ritz, MAM Ahmed, VV Bamm… - Journal of biomolecular …, 2015 - Springer
Direct proton detection is becoming an increasingly popular method for enhancing
sensitivity in solid-state nuclear magnetic resonance spectroscopy. Generally, these …

The effects of threonine phosphorylation on the stability and dynamics of the central molecular switch region of 18.5-kDa myelin basic protein

KA Vassall, K Bessonov, M De Avila, E Polverini… - PloS one, 2013 - journals.plos.org
The classic isoforms of myelin basic protein (MBP) are essential for the formation and
maintenance of myelin in the central nervous system of higher vertebrates. The protein is …

Recognition pliability is coupled to structural heterogeneity: a calmodulin intrinsically disordered binding region complex

M Nagulapalli, G Parigi, J Yuan, J Gsponer, G Deraos… - Structure, 2012 - cell.com
Protein interactions within regulatory networks should adapt in a spatiotemporal-dependent
dynamic environment, in order to process and respond to diverse and versatile cellular …

Chronic spinal cord compression associated with intervertebral disc degeneration in SPARC-null mice

ZY Li, AF Zhou, G Li, LY Zhou, PM Pu… - Neural Regeneration …, 2023 - journals.lww.com
Chronic spinal cord compression (CSCC) is induced by disc herniation and other reasons,
leading to movement and sensation dysfunction, with a serious impact on quality of life …

Solid-state NMR spectroscopic trends for supramolecular assemblies and protein aggregates

R Linser - Solid State Nuclear Magnetic Resonance, 2017 - Elsevier
Solid-state NMR is able to generate structural data on sample preparations that are explicitly
non-crystalline. In particular, for amyloid fibril samples, which can comprise significant …