[HTML][HTML] Natural Products–Pyrazine Hybrids: A Review of Developments in Medicinal Chemistry
GQ Chen, HY Guo, ZS Quan, QK Shen, X Li, T Luan - Molecules, 2023 - mdpi.com
Pyrazine is a six-membered heterocyclic ring containing nitrogen, and many of its
derivatives are biologically active compounds. References have been downloaded through …
derivatives are biologically active compounds. References have been downloaded through …
Antitubercular drugs induced liver injury: an updated insight into molecular mechanisms
D Ezhilarasan - Drug metabolism reviews, 2023 - Taylor & Francis
Tuberculosis (TB) remains a major global health burden. Antitubercular drugs (ATDs) such
as isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA), and ethambutol are used as first …
as isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA), and ethambutol are used as first …
In silico drug design strategies for discovering novel tuberculosis therapeutics
CSC Canales, AR Pavan, JL Dos Santos… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Tuberculosis remains a significant concern in global public health due to its
intricate biology and propensity for developing antibiotic resistance. Discovering new drugs …
intricate biology and propensity for developing antibiotic resistance. Discovering new drugs …
[HTML][HTML] HIV infection predisposes to increased chances of HBV infection: current understanding of the mechanisms favoring HBV infection at each clinical stage of …
SD Zaongo, J Ouyang, Y Chen, YM Jiao, H Wu… - Frontiers in …, 2022 - frontiersin.org
Human immunodeficiency virus (HIV) selectively targets and destroys the infection-fighting
CD4+ T-lymphocytes of the human immune system, and has a life cycle that encompasses …
CD4+ T-lymphocytes of the human immune system, and has a life cycle that encompasses …
[HTML][HTML] The prevalence, clinical reasoning and impact of non-standard anti-tuberculosis regimens at the initial prescription
RT Chen, CY Liu, SY Lin, CC Shu, WH Sheng - Scientific Reports, 2024 - nature.com
Regarding clinically-concerning non-standard initial anti-tuberculous (TB) regimens, few
studies have examined their prevalence, risk factors and impacts. We recruited patients with …
studies have examined their prevalence, risk factors and impacts. We recruited patients with …
Prussian blue (PB) modified gold nanoparticles as a SERS-based sensing platform for capturing and detection of pyrazinoic acid (POA)
C Liu, G Jiménez-Avalos, W Zhang, P Sheen, M Zimic… - Talanta, 2024 - Elsevier
Pyrazinoic acid (POA) is a metabolite of the anti-tuberculosis drug pyrazinamide (PZA), and
its detection can be used to assess the resistance of Mycobacterium tuberculosis in cultures …
its detection can be used to assess the resistance of Mycobacterium tuberculosis in cultures …
Pyrazinamide resistance and pncA mutation profiles in multidrug resistant Mycobacterium tuberculosis
D Shi, Q Zhou, S Xu, Y Zhu, H Li… - Infection and Drug …, 2022 - Taylor & Francis
Purpose Pyrazinamide (PZA) is a critical component of standardized chemotherapy for
tuberculosis (TB) and is recommended for the treatment of multidrug-resistant (MDR) TB. We …
tuberculosis (TB) and is recommended for the treatment of multidrug-resistant (MDR) TB. We …
[PDF][PDF] Incidence and predictors of adverse drug events among people receiving drug resistant tuberculosis treatment in Uganda: 8-year Retrospective Cohort Study
M Nasasira, JN Kalyango, E Mupere… - … and Clinical Risk …, 2022 - Taylor & Francis
Background Adverse drug events (ADEs) are regarded as the most essential therapeutic
issue during management of drug-resistant tuberculosis (DR-TB) due to the long duration of …
issue during management of drug-resistant tuberculosis (DR-TB) due to the long duration of …
Anti-tuberculosis drug-induced liver injury
WS Lim, A Avery, OM Kon, M Dedicoat - bmj, 2023 - bmj.com
Patients may not recognise or report early symptoms of anti-tuberculosis drug-induced liver
injury (DILI) due to their non-specific nature and overlap with symptoms arising from active …
injury (DILI) due to their non-specific nature and overlap with symptoms arising from active …
Application of a physiologically based pharmacokinetic model to predict isoniazid disposition during pregnancy
OU Amaeze, N Isoherranen - Clinical and Translational …, 2023 - Wiley Online Library
Pregnancy can increase the risk of latent tuberculosis infection (LTBI) progression to
tuberculosis (TB) disease. Isoniazid (INH) is the preferred preventative treatment for LTBI in …
tuberculosis (TB) disease. Isoniazid (INH) is the preferred preventative treatment for LTBI in …