Pyrazine is a six-membered heterocyclic ring containing nitrogen, and many of its
derivatives are biologically active compounds. References have been downloaded through …

Tuberculosis (TB) remains a major global health burden. Antitubercular drugs (ATDs) such
as isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA), and ethambutol are used as first …

Introduction Tuberculosis remains a significant concern in global public health due to its
intricate biology and propensity for developing antibiotic resistance. Discovering new drugs …

Human immunodeficiency virus (HIV) selectively targets and destroys the infection-fighting
CD4+ T-lymphocytes of the human immune system, and has a life cycle that encompasses …

Regarding clinically-concerning non-standard initial anti-tuberculous (TB) regimens, few
studies have examined their prevalence, risk factors and impacts. We recruited patients with …

Pyrazinoic acid (POA) is a metabolite of the anti-tuberculosis drug pyrazinamide (PZA), and
its detection can be used to assess the resistance of Mycobacterium tuberculosis in cultures …

Purpose Pyrazinamide (PZA) is a critical component of standardized chemotherapy for
tuberculosis (TB) and is recommended for the treatment of multidrug-resistant (MDR) TB. We …

Background Adverse drug events (ADEs) are regarded as the most essential therapeutic
issue during management of drug-resistant tuberculosis (DR-TB) due to the long duration of …

Patients may not recognise or report early symptoms of anti-tuberculosis drug-induced liver
injury (DILI) due to their non-specific nature and overlap with symptoms arising from active …

Pregnancy can increase the risk of latent tuberculosis infection (LTBI) progression to
tuberculosis (TB) disease. Isoniazid (INH) is the preferred preventative treatment for LTBI in …