Exposure of biological molecules to oxidants is inevitable and therefore commonplace.
Oxidative stress in cells arises from both external agents and endogenous processes that …

The self-assembly of proteins is an essential process for a variety of cellular functions
including cell respiration, mobility and division. On the other hand, protein or peptide …

Protein instability caused by exposure to external additives or severe stress may result in
different diseases. Of these diseases, many are triggered by protein misfolding and …

Coacervates droplets have long been considered as potential protocells to mimic living
cells. However, these droplets lack a membrane and are prone to coalescence, limiting their …

Significance: Essential metals such as copper, iron, manganese, and zinc play a role as
cofactors in the activity of a wide range of processes involved in cellular homeostasis and …

Genetic background accounts for only 5 to 10% of the reported cases of Parkinson's disease
(PD), while the remaining cases are of unknown etiology. It is believed that environmental …

Covalent crosslinks within or between proteins play a key role in determining the structure
and function of proteins. Some of these are formed intentionally by either enzymatic or …

Intrinsically disordered proteins (IDPs) are implicated in many human diseases. They have
generally not been amenable to conventional structure-based drug design, however …

Amyloid fibril formation of α-synuclein (αS) is associated with multiple neurodegenerative
diseases, including Parkinson's disease (PD). Growing evidence suggests that progression …

Alzheimer's disease is characterized by the self-assembly of tau and amyloid β proteins into
oligomers and fibrils. Tau protein assembles into paired helical filaments (PHFs) that …