[HTML][HTML] Hidden pharmacological activities of valproic acid: A new insight
Valproic acid (VPA) is an approved drug for managing epileptic seizures, bipolar disorders,
and migraine. VPA has been shown to elevate the level of gamma-aminobutyric acid …
and migraine. VPA has been shown to elevate the level of gamma-aminobutyric acid …
Polysaccharide from Rosa roxburghii Tratt Fruit Attenuates Hyperglycemia and Hyperlipidemia and Regulates Colon Microbiota in Diabetic db/db Mice
This study was aimed at investigating the hypoglycemic and hypolipidemic effects of a
polysaccharide (RTFP) isolated from Rosa roxburghii Tratt fruit on type-2 diabetic db/db …
polysaccharide (RTFP) isolated from Rosa roxburghii Tratt fruit on type-2 diabetic db/db …
Identification and molecular docking study of sugarcane leaf‐derived compounds as potent dipeptidyl peptidase IV, α‐glucosidase, and α‐amylase inhibitors
R Kan, P Ren, AX Wu, Q Tang… - Journal of the Science …, 2023 - Wiley Online Library
Abstract BACKGROUND Dipeptidyl peptidase‐IV (DPP‐IV), α‐glucosidase, and α‐amylase
play a prominent role in regulating postprandial blood sugar levels, which are regarded as …
play a prominent role in regulating postprandial blood sugar levels, which are regarded as …
Akkermansia muciniphila can reduce the damage of gluco/lipotoxicity, oxidative stress and inflammation, and normalize intestine microbiota in streptozotocin-induced …
L Zhang, Q Qin, M Liu, X Zhang, F He… - Pathogens and …, 2018 - academic.oup.com
This study aimed to investigate how Akkermansia muciniphila can implicate type 2 diabetes
mellitus and the mechanisms underlying the effects A. muciniphila on type 2 diabetes …
mellitus and the mechanisms underlying the effects A. muciniphila on type 2 diabetes …
Hypoglycemic and hypolipidemic effects of anthocyanins extract from black soybean seed coat in high fat diet and streptozotocin-induced diabetic mice
Z Chen, C Wang, Y Pan, X Gao, H Chen - Food & function, 2018 - pubs.rsc.org
Black soybean seed coat extract (BSSCE) is a rich source of anthocyanins with multiple
health effects. This study was aimed at investigating the composition and hypoglycemic and …
health effects. This study was aimed at investigating the composition and hypoglycemic and …
Hypoglycemic and hypolipidemic effects of a polysaccharide from flower buds of Lonicera japonica in streptozotocin-induced diabetic rats
D Wang, X Zhao, Y Liu - International Journal of Biological Macromolecules, 2017 - Elsevier
Hyperglycemia and dyslipidemia are classic features for diabetes mellitus (DM). In this
study, one fraction of the crude polysaccharides extracted from Lonicera japonica flower …
study, one fraction of the crude polysaccharides extracted from Lonicera japonica flower …
Structure Characterization and Hypoglycaemic Activities of Two Polysaccharides from Inonotus obliquus
P Liu, J Xue, S Tong, W Dong, P Wu - Molecules, 2018 - mdpi.com
In the present study, two polysaccharides (HIOP1-S and HIOP2-S) were isolated and
purified from Inonotus obliquus using DEAE-52 cellulose and Sephadex G-100 column …
purified from Inonotus obliquus using DEAE-52 cellulose and Sephadex G-100 column …
Valproic acid improves glucose homeostasis by increasing beta‐cell proliferation, function, and reducing its apoptosis through HDAC inhibition in juvenile diabetic rat
Recent evidence highlighted that there is a link between type‐1 diabetes mellitus and
histone deacetylases (HDACs) due to their involvement in beta‐cell differentiation …
histone deacetylases (HDACs) due to their involvement in beta‐cell differentiation …
Valproic acid reduces insulin-resistance, fat deposition and FOXO1-mediated gluconeogenesis in type-2 diabetic rat
Recent evidences highlighted the role of histone deacetylases (HDACs) in insulin-
resistance, gluconeogenesis and islet function. HDACs can modulate the expression of …
resistance, gluconeogenesis and islet function. HDACs can modulate the expression of …
Repurposing of sodium valproate in colon cancer associated with diabetes mellitus: Role of HDAC inhibition
Background and purpose Diabetic patients are at greater risk for colon cancer. Histone
deacetylases (HDACs) serve as common target for both. The key objective of the study was …
deacetylases (HDACs) serve as common target for both. The key objective of the study was …