Dense granule biogenesis, secretion, and function in Toxoplasma gondii
MB Griffith, CS Pearce… - Journal of Eukaryotic …, 2022 - Wiley Online Library
Toxoplasma gondii is an obligate intracellular parasite and the causative agent of
Toxoplasmosis. A key to understanding and treating the disease lies with determining how …
Toxoplasmosis. A key to understanding and treating the disease lies with determining how …
The determinants regulating Toxoplasma gondii bradyzoite development
M Pan, CC Ge, YM Fan, QW Jin, B Shen… - Frontiers in …, 2022 - frontiersin.org
Toxoplasma gondii is an obligate intracellular zoonotic pathogen capable of infecting almost
all cells of warm-blooded vertebrates. In intermediate hosts, this parasite reproduces …
all cells of warm-blooded vertebrates. In intermediate hosts, this parasite reproduces …
CRISPR Screens Identify Toxoplasma Genes That Determine Parasite Fitness in Interferon Gamma-Stimulated Human Cells
Toxoplasma virulence depends on its ability to evade or survive the toxoplasmacidal
mechanisms induced by interferon gamma (IFNγ). While many Toxoplasma genes involved …
mechanisms induced by interferon gamma (IFNγ). While many Toxoplasma genes involved …
[HTML][HTML] Host genetics highlights IFN-γ-dependent Toxoplasma genes encoding secreted and non-secreted virulence factors in in vivo CRISPR screens
Y Tachibana, E Hashizaki, M Sasai, M Yamamoto - Cell Reports, 2023 - cell.com
Secreted virulence factors of Toxoplasma to survive in immune-competent hosts have been
extensively explored by classical genetics and in vivo CRISPR screen methods, whereas …
extensively explored by classical genetics and in vivo CRISPR screen methods, whereas …
ROP16-mediated activation of STAT6 enhances cyst development of type III Toxoplasma gondii in neurons
JA Kochanowsky, S Chandrasekaran… - PLoS …, 2023 - journals.plos.org
Toxoplasma gondii establishes a long-lived latent infection in the central nervous system
(CNS) of its hosts. Reactivation in immunocompromised individuals can lead to life …
(CNS) of its hosts. Reactivation in immunocompromised individuals can lead to life …
Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons
S Bracha, HJ Johnson, NA Pranckevicius, F Catto… - Nature …, 2024 - nature.com
Delivering macromolecules across biological barriers such as the blood–brain barrier limits
their application in vivo. Previous work has demonstrated that Toxoplasma gondii, a parasite …
their application in vivo. Previous work has demonstrated that Toxoplasma gondii, a parasite …
Toxoplasma protein export and effector function
Toxoplasma gondii is a single-celled eukaryotic parasite with a considerable host range that
must invade the cells of warm-blooded hosts to survive and replicate. The challenges and …
must invade the cells of warm-blooded hosts to survive and replicate. The challenges and …
Prevalence of Toxoplasma gondii IgG Antibodies and Associated Risk Factors in Psychiatric Patients from Western Romania: A Cross-Sectional Study
S Grada, AG Mihu, DA Oatis, M Susan, MA Lupu… - Microorganisms, 2024 - mdpi.com
Infection with the coccidian parasite Toxoplasma gondii was associated with an increased
risk of several mental disorders. We conducted a case–control study of 464 consecutive …
risk of several mental disorders. We conducted a case–control study of 464 consecutive …
A Review of Immunological and Neuropsychobehavioral Effects of Latent Toxoplasmosis on Humans
M Kazemi Arababadi, SH Abdollahi… - Parasite …, 2024 - Wiley Online Library
Toxoplasmosis as a zoonotic disease has a worldwide distribution and can infect a wide
range of animal hosts, as well as at least one third of the world's human population. The …
range of animal hosts, as well as at least one third of the world's human population. The …
Unveiling of brain transcriptome of masked palm civet (Paguma larvata) with chronic infection of Toxoplasma gondii
H Yuan, XX Zhang, ZP Yang, XH Wang… - Parasites & …, 2022 - Springer
Background The aim of this study was to gain an understanding of the transcriptomic
changes that occur in a wild species when infected with Toxoplasma gondii. The masked …
changes that occur in a wild species when infected with Toxoplasma gondii. The masked …