Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation

M Chehelgerdi, M Chehelgerdi, OQB Allela… - Molecular cancer, 2023 - Springer
The use of nanotechnology has the potential to revolutionize the detection and treatment of
cancer. Developments in protein engineering and materials science have led to the …

Unlocking the potential of mesoporous silica nanoparticles in breast cancer treatment

R Thapa, H Ali, O Afzal, AA Bhat, WH Almalki… - Journal of Nanoparticle …, 2023 - Springer
Breast cancer is the most common cancer among women and is typically managed through
surgery, radiation therapy, and chemotherapy. However, chemotherapy drugs often lack …

[HTML][HTML] Nanotechnology-based strategies for treatment of ocular disease

Y Weng, J Liu, S Jin, W Guo, X Liang, Z Hu - Acta pharmaceutica sinica B, 2017 - Elsevier
Ocular diseases include various anterior and posterior segment diseases. Due to the unique
anatomy and physiology of the eye, efficient ocular drug delivery is a great challenge to …

Establishing the effects of mesoporous silica nanoparticle properties on in vivo disposition using imaging-based pharmacokinetics

P Dogra, NL Adolphi, Z Wang, YS Lin, KS Butler… - Nature …, 2018 - nature.com
The progress of nanoparticle (NP)-based drug delivery has been hindered by an inability to
establish structure-activity relationships in vivo. Here, using stable, monosized, radiolabeled …

Mathematical modeling in cancer nanomedicine: a review

P Dogra, JD Butner, Y Chuang, S Caserta, S Goel… - Biomedical …, 2019 - Springer
Cancer continues to be among the leading healthcare problems worldwide, and efforts
continue not just to find better drugs, but also better drug delivery methods. The need for …

Design of Water–Soluble Rotaxane-Capped Superparamagnetic, Ultrasmall Fe3O4 Nanoparticles for Targeted NIR Fluorescence Imaging in Combination with …

RS Das, D Maiti, S Kar, T Bera… - Journal of the …, 2023 - ACS Publications
Integrating an NIR fluorescent probe with a magnetic resonance imaging (MRI) agent to
harvest complementary imaging information is challenging. Here, we have designed water …

H2O2 Self-Supply and Glutathione Depletion Engineering Nanoassemblies for NIR-II Photoacoustic Imaging of Tumor Tissues and Photothermal-Enhanced Gas …

Y Luo, L Zhang, S Wang, Y Wang, J Hua… - … Applied Materials & …, 2023 - ACS Publications
The development of tumor microenvironment (TME)-activated nanoassemblies which can
produce a photoacoustic (PA) signal and enhance the H2O2 level is critical to achieve …

Biomolecular engineering for nanobio/bionanotechnology

T Nagamune - Nano convergence, 2017 - Springer
Biomolecular engineering can be used to purposefully manipulate biomolecules, such as
peptides, proteins, nucleic acids and lipids, within the framework of the relations among their …

[HTML][HTML] A mathematical model to predict nanomedicine pharmacokinetics and tumor delivery

P Dogra, JD Butner, JR Ramírez, Y Chuang… - Computational and …, 2020 - Elsevier
Towards clinical translation of cancer nanomedicine, it is important to systematically
investigate the various parameters related to nanoparticle (NP) physicochemical properties …

Remotely controlled magneto-regulation of therapeutics from magnetoelastic gel matrices

S Ganguly, S Margel - Biotechnology Advances, 2020 - Elsevier
Surface active magnetic nanoparticles especially superparamagnetic iron oxides are
already occupying a major domain in medical therapeutics. Arresting of these magnetic …