Biased agonism: An emerging paradigm in GPCR drug discovery
G protein coupled receptors have historically been one of the most druggable classes of
cellular proteins. The members of this large receptor gene family couple to primary effectors …
cellular proteins. The members of this large receptor gene family couple to primary effectors …
Clerodane diterpenes: sources, structures, and biological activities
R Li, SL Morris-Natschke, KH Lee - Natural product reports, 2016 - pubs.rsc.org
Covering: 1990 to 2015 The clerodane diterpenoids are a widespread class of secondary
metabolites and have been found in several hundreds of plant species from various families …
metabolites and have been found in several hundreds of plant species from various families …
Mitragynine/corynantheidine pseudoindoxyls as opioid analgesics with mu agonism and delta antagonism, which do not recruit β-arrestin-2
Natural products found in Mitragyna speciosa, commonly known as kratom, represent
diverse scaffolds (indole, indolenine, and spiro pseudoindoxyl) with opioid activity, providing …
diverse scaffolds (indole, indolenine, and spiro pseudoindoxyl) with opioid activity, providing …
Natural products for the treatment of pain: chemistry and pharmacology of salvinorin A, mitragynine, and collybolide
S Chakraborty, S Majumdar - Biochemistry, 2020 - ACS Publications
Pain remains a very pervasive problem throughout medicine. Classical pain management is
achieved through the use of opiates belonging to the mu opioid receptor (MOR) class, which …
achieved through the use of opiates belonging to the mu opioid receptor (MOR) class, which …
Neuropharmacology of the naturally occurring κ-opioid hallucinogen salvinorin A
Salvia divinorum is a perennial sage native to Oaxaca, Mexico, that has been used
traditionally in divination rituals and as a treatment for the “semimagical” disease panzón de …
traditionally in divination rituals and as a treatment for the “semimagical” disease panzón de …
Endogenous opiates and behavior: 2006
RJ Bodnar - Peptides, 2007 - Elsevier
This paper is the 29th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning 30 years of research. It summarizes papers …
the endogenous opioid system, now spanning 30 years of research. It summarizes papers …
[HTML][HTML] From plant to chemistry: Sources of active opioid antinociceptive principles for medicinal chemistry and drug design
R Turnaturi, S Piana, S Spoto, G Costanzo, L Reina… - Molecules, 2023 - mdpi.com
Pain continues to be an enormous global health challenge, with millions of new untreated or
inadequately treated patients reported annually. With respect to current clinical applications …
inadequately treated patients reported annually. With respect to current clinical applications …
Analgesic opioid ligand discovery based on nonmorphinan scaffolds derived from natural sources
Strong opioid analgesics, including morphine, are the mainstays for treating moderate to
severe acute pain and alleviating chronic cancer pain. However, opioid-related adverse …
severe acute pain and alleviating chronic cancer pain. However, opioid-related adverse …
A review of salvinorin analogs and their kappa-opioid receptor activity
JJ Roach, RA Shenvi - Bioorganic & medicinal chemistry letters, 2018 - Elsevier
The plant metabolite salvinorin A potently and selectively agonizes the human kappa-opioid
receptor, an emerging target for next-generation analgesics. Here we review analogs of the …
receptor, an emerging target for next-generation analgesics. Here we review analogs of the …
Salvinorin A analogs as probes in opioid pharmacology
TE Prisinzano, RB Rothman - Chemical reviews, 2008 - ACS Publications
The opium poppy, PapaVer somniferum, is one of several plants that have profoundly
affected human history. 1 It has provided an unmatched medicine for the relief of pain for …
affected human history. 1 It has provided an unmatched medicine for the relief of pain for …